# First person – Victor Tapia

## TL;DR

This paper explores how 25-hydroxycholesterol affects brain blood vessel dysfunction during infection and cholesterol issues.

## Contribution

The study identifies a new role for 25-hydroxycholesterol in brain vessel dysfunction linked to infection and cholesterol dysregulation.

## Key findings

- 25-hydroxycholesterol contributes to brain vessel dysfunction during infection.
- Cholesterol dysregulation exacerbates vascular issues in the brain.
- Findings suggest potential neuroprotective strategies for intracerebral haemorrhage.

## Abstract

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Victor Tapia is first author on ‘
The role of 25-hydroxycholesterol in the pathophysiology of brain vessel dysfunction associated with infection and cholesterol dysregulation’, published in DMM. Victor is a postdoctoral research associate in the lab of Catherine Lawrence and Paul Kasher at The University of Manchester, Manchester, UK, investigating the causes and neuroprotective mechanisms of intracerebral haemorrhage using in vitro and animal experimental models.