How to Integrate Echocardiographic Risk Factors for Atrial Fibrillation Following Acute Myocardial Infarction
Naoya Kataoka, Teruhiko Imamura

Abstract
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- —The authors received no specific funding for this work.
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Taxonomy
TopicsAtrial Fibrillation Management and Outcomes · Cardiac Imaging and Diagnostics · Cardiovascular Function and Risk Factors
To Editor,
1
De novo atrial fibrillation (AF) following cardiac interventions frequently recurs, and early detection is particularly crucial in patients with acute myocardial infarction (AMI). The authors of the present study demonstrated that several echocardiographic parameters reflecting left atrial function were associated with the subsequent development of AF following AMI [1]. However, several concerns merit discussion.
Defining true de novo AF can be inherently challenging, as asymptomatic or subclinical AF may go undetected. How did the authors exclude the possibility of pre‐existing silent AF before the onset of AMI? Such undiagnosed episodes may have contributed to the observed left atrial remodeling.
The study population was limited to patients with AMI [1], in whom AF development is often precipitated by systemic inflammation or left atrial ischemia [2, 3]. Did the authors identify any supportive evidence for these mechanisms? For example, occlusion of the right coronary artery or left circumflex artery—both of which may involve atrial branches—could plausibly be linked to AF onset.
From a practical standpoint, how might these findings be applied in real‐world clinical settings? Even if we succeed in identifying patients at high risk, continuous rhythm monitoring using standard modalities would still be required for AF detection. Alternatively, could prophylactic catheter ablation be considered in select high‐risk individuals? Additionally, given that patients routinely receive antiplatelet therapy after AMI, the timing and feasibility of left atrial appendage closure following AF detection warrant further clarification [4].
Ethics Statement
The authors have nothing to report.
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Conflicts of Interest
The authors declare no conflicts of interest.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1B. Jacuś , A. Milewska , P. Miękus , et al., “Assessment of Risk Factors for Atrial Fibrillation With a Particular Focus on Echocardiographic Parameters, in Patients With Acute Myocardial Infarction,” Clinical Cardiology 48 (2025): e 70114, 10.1002/clc.70114.40152152 PMC 11950838 · doi ↗ · pubmed ↗
- 2D. Dobrev , M. Aguilar , J. Heijman , J. B. Guichard , and S. Nattel , “Postoperative Atrial Fibrillation: Mechanisms, Manifestations and Management,” Nature Reviews Cardiology 16 (2019): 417–436, 10.1038/s 41569-019-0166-5.30792496 · doi ↗ · pubmed ↗
- 3K. Nishida , X. Y. Qi , R. Wakili , et al., “Mechanisms of Atrial Tachyarrhythmias Associated With Coronary Artery Occlusion in a Chronic Canine Model,” Circulation 123 (2011): 137–146, 10.1161/circulationaha.110.972778.21200008 · doi ↗ · pubmed ↗
- 4O. M. Wazni , W. I. Saliba , D. G. Nair , et al., “Left Atrial Appendage Closure After Ablation for Atrial Fibrillation,” New England Journal of Medicine 392 (2025): 1277–1287, 10.1056/NEJ Moa 2408308.39555822 · doi ↗ · pubmed ↗
