# Clinical efficacy of OS‐01 peptide formulation in reducing the signs of periorbital skin aging

## TL;DR

A new eye cream containing OS-01 peptide improved skin hydration, firmness, and reduced aging signs like wrinkles and puffiness around the eyes over 12 weeks.

## Contribution

The study introduces OS-01 EYE, a senomorphic peptide formulation, as a novel and effective treatment for periorbital skin aging.

## Key findings

- OS-01 EYE significantly improved skin hydration by 32.49% and reduced transepidermal water loss by 17.33%.
- Expert evaluations showed reduced fine lines, wrinkles, under-eye puffiness, and dark circles after 12 weeks of use.
- 95.46% of participants reported visible improvements in their periorbital skin appearance.

## Abstract

The aging of the skin, particularly around the periorbital region, is a complex process characterized by the accumulation of senescent cells, decreased collagen production, and reduced skin elasticity, leading to visible signs such as fine lines, wrinkles, and sagging.

This study investigates the efficacy of a novel topical formulation, OS‐01 EYE, containing the senomorphic peptide, OS‐01, along with other active ingredients, in improving the skin around the eyes.

A 12‐week clinical study was conducted with 22 participants who applied OS‐01 EYE twice daily. Assessments included bioinstrumental measurements of skin hydration, barrier function, firmness, and elasticity, as well as expert photographs grading fine lines, wrinkles, under‐eye puffiness, and dark circles.

After 12 weeks of product use, transepidermal water loss (TEWL) decreased by 17.33%, hydration increased by 32.49%, skin firmness improved by 10.19%, and elasticity increased by 25.58%, compared to baseline, which was all statistically significant. Expert grading revealed a decrease in fine lines and wrinkles, under‐eye puffiness, and dark circles over the study period. Furthermore, subjective assessments showed that 95.46% of participants reported improvements in overall appearance.

The OS‐01 EYE formulation was found to be safe and effective in mitigating the visible signs of aging in the periorbital region, making it a potent treatment option for enhancing periorbital skin health, function, and appearance.

In a 12‐week clinical study, a formulation containing the senotherapeutic peptide OS‐01 effectively reduced fine lines and enhanced skin hydration, firmness, and elasticity in the periorbital region. Additionally, expert evaluations and self‐reported participant feedback validated the formulation's efficacy and safety.