# Clinical features and management of postoperative lumbar intervertebral space infections following spinal endoscopy: a retrospective analysis

**Authors:** Kunpeng Su, Mingzhi Liu, Mengxuan Wang, Qingyu Yao, Zirui Wang, Zheng Lian, Chuanli Zhou

PMC · DOI: 10.3389/fcimb.2025.1538779 · Frontiers in Cellular and Infection Microbiology · 2025-05-19

## TL;DR

This study analyzes the clinical features and treatment of rare but serious infections that can occur after spinal endoscopy, emphasizing the importance of early diagnosis and proper management.

## Contribution

The study provides a retrospective analysis of clinical characteristics, risk factors, and treatment strategies for postoperative intervertebral space infections following spinal endoscopy.

## Key findings

- Common symptoms include localized back pain, neurological deficits, and fever, but they are nonspecific.
- MRI is valuable for early diagnosis, and elevated inflammatory markers like CRP and ESR are frequently observed.
- Effective treatment involves surgical debridement, internal fixation, and prolonged antibiotic therapy.

## Abstract

Postoperative lumbar intervertebral space infections following spinal endoscopy are infrequent but severe complications that can markedly affect patient recovery and treatment outcomes. Early diagnosis remains challenging due to the nonspecific nature of clinical symptoms. This study aims to identify the clinical characteristics, risk factors, and effective diagnostic and treatment strategies for postoperative intervertebral space infections.

A retrospective analysis was conducted on 14 cases of postoperative intervertebral space infections following spinal endoscopy. The data set included patient demographics, clinical symptoms, imaging findings, blood culture results, and treatment approaches. The analysis assessed early diagnosis and treatment outcomes concerning the infection’s progression and the use of MRI, inflammatory markers, and empirical antibiotics.

The most common clinical symptoms included localized back pain, neurological deficits, and fever, though these lacked specificity. MRI proved valuable in diagnosing early infections. The majority of cases exhibited elevated levels of inflammatory markers, such as CRP and ESR. The treatment plan included early surgical intervention with debridement and internal fixation, along with extended antibiotic therapy.

The early identification and intervention of postoperative intervertebral space infections following spinal endoscopy are of critical importance. The implementation of a strict aseptic technique, the execution of careful preoperative planning, and the timely use of MRI for diagnosis are essential to the prevention and effective treatment of these infections. This study underscores the necessity of a comprehensive approach to minimize the risk of postoperative intervertebral space infections and to enhance patient outcomes.

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** intervertebral space infections (MESH:D008158), neurological deficits (MESH:D009461), fever (MESH:D005334), back pain (MESH:D001416), infection (MESH:D007239), inflammatory (MESH:D007249)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC12127424/full.md

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Source: https://tomesphere.com/paper/PMC12127424