# Natural products in treating diabetic kidney disease: a visualized bibliometric analysis

## TL;DR

This study maps research trends in using natural products for diabetic kidney disease, highlighting China's leadership and emerging research areas like network pharmacology.

## Contribution

A bibliometric analysis revealing collaboration patterns and emerging research trends in natural products for diabetic kidney disease.

## Key findings

- China leads in research output with Li Ping as the top contributor and Zhang Lei’s work being most cited.
- Network pharmacology, molecular docking, and gut microbiota are key research hotspots in natural product studies for DKD.
- Future research trends suggest integrating network pharmacology with artificial intelligence and big data.

## Abstract

Diabetic kidney disease (DKD) is one of the most significant complications in diabetic patients, yet current therapeutic options are limited. The advantages of natural products in treating chronic diseases have increasingly garnered attention. This study aims to map the landscape of natural products in DKD and provide new insights for future research in this field.

Literature retrieval was conducted through the Web of Science. CiteSpace and VOSviewer were employed to conduct visual analyses of these papers.

A total of 523 literature were obtained, originating from 655 institutions across 40 countries/regions and involving 3,116 authors. These literature were published in 178 journals. The results indicate that China leads in this field, with Li Ping contributing the most publications. Zhang Lei’s work has been cited the most. Journal of Ethnopharmacology is the most popular journal. The paper with the highest average annual citation rate is authored by Tang, GY. Keyword analysis reveals that systematic biological approaches such as network pharmacology, molecular docking, and gut microbiota have become hotspots in this field.

Natural products exhibit positive pharmacological activity and therapeutic value in the treatment of DKD. Extensive cooperation and communication among countries, institutions, and authors still need to be strengthened to promote basic research and clinical applications of natural products. Besides, the deep integration of network pharmacology with artificial intelligence and big data represents a hot topic and trend in future research on natural products against DKD.