# Paul Hoffmann and the cutaneous silent period test

**Authors:** Otto Jesus Hernández Fustes, Cláudia Suemi Kamoi Kay, Paulo José Lorenzoni, Renata Dal-Prá Ducci, Paula Raquel do Vale Pascoal Rodrigues, Rosana Herminia Scola

PMC · DOI: 10.1055/s-0045-1806826 · Arquivos de Neuro-Psiquiatria · 2025-06-01

## TL;DR

This paper discusses the life and work of Paul Hoffmann, focusing on his 1922 development of the cutaneous silent period test for neurophysiology.

## Contribution

The paper highlights the historical significance and clinical impact of the cutaneous silent period test introduced by Hoffmann.

## Key findings

- The cutaneous silent period test was a novel neurophysiological technique when introduced in 1922.
- Hoffmann's work has had lasting importance in clinical neurophysiology and diagnostic applications.
- The paper reviews the clinical relevance and evolution of the cutaneous silent period test.

## Abstract

We herein present aspects of the biography of Professor Paul Hoffmann, covering his main works, mainly the article describing the cutaneous silent period, a new technique when it was published in 1922, with a review of its importance, its role in clinical neurophysiology, and its clinical application.

## Full-text entities

- **Genes:** DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5) [NCBI Gene 80331] {aka CLN4, CLN4B, CSP, DNAJC5A, mir-941-2, mir-941-3}
- **Diseases:** diseases of the central nervous system (MESH:D002493), myelopathy (MESH:D013118), axonal polyneuropathies (MESH:D011115), small-fiber neuropathies (MESH:D000071075), heart attack (MESH:D009203), intramedullary lesions (MESH:D013120), tumors (MESH:D009369), nerve injury (MESH:D000080902), SILENT PERIOD TEST (MESH:C566065)
- **Chemicals:** PAUL (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12127044/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12127044/full.md

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Source: https://tomesphere.com/paper/PMC12127044