# A Comparative Study of the Outcomes of Surgically Versus Non‐Surgically Treated Spinal Disease in Patients With Multiple Myeloma: Northern Ireland's Experience

## TL;DR

This study compares spinal surgery and non-surgery outcomes in multiple myeloma patients, finding that surgery may improve survival and prevent neurological issues.

## Contribution

The study provides new insights into the effectiveness of spinal surgery for multiple myeloma patients in Northern Ireland.

## Key findings

- Surgical patients had significantly longer survival (77 vs. 24 months) compared to non-surgical patients.
- Surgery may prevent neurological deterioration, as 23% of surgical patients improved neurologically.
- Back pain alone should not be an indication for spinal surgery in myeloma patients.

## Abstract

Multiple myeloma is a haematological malignancy which is characterised by the proliferation of cancerous plasma cells in the bone marrow. The role of spinal surgery in the management of myeloma is debatable. Therefore, this retrospective study aimed to compare the outcomes of treatment of patients with myeloma whose spinal disease was managed surgically and/or non‐surgically.

A total of 159 patients were reviewed retrospectively. To compare the outcomes of treatment in both cohorts, three outcome measures were selected, including back‐pain reduction, neurological status, and survival duration.  In addition, the extent and distribution of vertebral disease was assessed using MRI Whole Spine reports.

There was no significant difference in the percentage of patients in each cohort reporting back‐pain pretreatment and at the two follow‐up periods (p > 0.05). Regarding neurological status, 23% of the surgical cohort improved, 53% remained stable and 7% deteriorated. In comparison, the non‐surgical cohort displayed no significant changes in neurological status post‐treatment. The mean duration of survival was significantly longer in the cohort who received surgery (77 vs. 24 months, p = 0.014). However, the mean age of diagnosis was significantly lower in this cohort (59 vs. 71 years, p < 0.001). T12 was the most commonly diseased vertebral level across both cohorts. At the time of diagnosis, the average number of diseased vertebrae per patient was 3.5 in the surgical cohort and 3.6 in the non‐surgical cohort.

This comparative study has shown that back pain alone should not be an indication for spinal surgery. However, surgical intervention may successfully prevent neurological deterioration. Although surgical intervention is associated with prolonged survival, this may be confounded by demographic variables, such as age. Importantly, most patients displayed multi‐level disease at the time of diagnosis.

The authors have confirmed clinical trial registration is not needed for this submission.