# FIP1L1‐PDGFRA Positive Chronic Eosinophilic Leukemia Presenting With Vestibular Neuritis

**Authors:** Ahmad Abu‐Zahra, Mahfujul Z. Haque, Abdulmalik Saleem, Arif Hussain, Ferdous Nipu

PMC · DOI: 10.1002/ccr3.70554 · Clinical Case Reports · 2025-05-30

## TL;DR

A rare case of chronic eosinophilic leukemia with a PDGFRA gene rearrangement presented with symptoms resembling vestibular neuritis in a 53-year-old man.

## Contribution

This case highlights a rare presentation of chronic eosinophilic leukemia associated with a PDGFRA gene rearrangement.

## Key findings

- The patient exhibited symptoms of vestibular neuritis linked to chronic eosinophilic leukemia.
- A PDGFRA gene rearrangement was identified in the patient's leukemia cells.

## Abstract

Myeloproliferative neoplasms are disorders of stem cells that result in excessive proliferation of one or more myeloid progenitors. We report a rare finding of chronic eosinophilic leukemia with a rearrangement of the PDGFRA gene in a 53‐year‐old male patient presenting with symptoms suggestive of vestibular neuritis.

## Linked entities

- **Genes:** PDGFRA (platelet derived growth factor receptor alpha) [NCBI Gene 5156]
- **Diseases:** chronic eosinophilic leukemia (MONDO:0015687)

## Full-text entities

- **Genes:** PDGFRA (platelet derived growth factor receptor alpha) [NCBI Gene 5156] {aka CD140A, PDGFR-2, PDGFR2}, FIP1L1 (factor interacting with PAPOLA and CPSF1) [NCBI Gene 81608] {aka FIP1, Rhe, hFip1}
- **Diseases:** Vestibular Neuritis (MESH:D020338), Myeloproliferative neoplasms (MESH:D009369), Chronic Eosinophilic Leukemia (MESH:C580364)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12124997/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12124997/full.md

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Source: https://tomesphere.com/paper/PMC12124997