# Dorsal Root Ganglion Stimulation in Patients With Refractory Abdominal Pain: A Case Series

**Authors:** Zeshan R Ali, Beker Karadaghy, Iqbal Khan, Geoffrey D Panjeton, Hess Panjeton

PMC · DOI: 10.7759/cureus.83218 · Cureus · 2025-04-29

## TL;DR

This study shows that stimulating the dorsal root ganglion can significantly reduce chronic abdominal pain in patients who do not respond to other treatments.

## Contribution

The novel contribution is demonstrating DRG stimulation's effectiveness for refractory abdominal pain in three distinct clinical cases.

## Key findings

- DRG stimulation led to 100%, 90%, and 80% pain reductions in patients with pancreatitis, endometriosis, and pancreatic cancer.
- Patients experienced improved daily functionality and reduced analgesic use after DRG stimulation.
- The results suggest DRG stimulation is a promising treatment for chronic abdominal pain unresponsive to conventional therapies.

## Abstract

This case series highlights the use of dorsal root ganglion (DRG) stimulation for refractory chronic abdominal pain in three patients who failed to respond to conventional therapies. DRG stimulation modulates pain signals by targeting the sensory neurons present in the DRG. The three cases involved patients with chronic abdominal pain resulting from pancreatitis, endometriosis, and pancreatic cancer. DRG stimulation resulted in pain reductions of 100%, 90%, and 80%, respectively, accompanied by significant improvements in daily functionality and reduced analgesic use. These findings underscore the potential of DRG stimulation as a targeted, effective treatment for refractory abdominal pain. Further research with larger cohorts is warranted to validate these results and refine treatment protocols.

## Linked entities

- **Diseases:** pancreatitis (MONDO:0004982), endometriosis (MONDO:0005133), pancreatic cancer (MONDO:0005192)

## Full-text entities

- **Diseases:** pain (MESH:D010146), endometriosis (MESH:D004715), Abdominal Pain (MESH:D015746), pancreatitis (MESH:D010195), pancreatic cancer (MESH:D010190)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12124893/full.md

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Source: https://tomesphere.com/paper/PMC12124893