# Prebiotic Interconversion of Pyruvate and Lactate over Zeolite‐Supported Ni Catalyst

## TL;DR

This study shows that nickel nanoparticles supported by zeolite can catalyze the conversion of pyruvate and lactate under hydrothermal vent conditions, potentially mimicking early prebiotic chemical processes.

## Contribution

The study demonstrates that zeolite-supported Ni nanoparticles can catalyze prebiotic pyruvate-lactate interconversion, mirroring biological lactate dehydrogenase activity.

## Key findings

- Ni/Y catalyzes pyruvate hydrogenation via in situ H₂ generation under hydrothermal conditions.
- XAS analysis reveals structural changes in Ni/Y, including nickel oxide/hydroxide and dealuminated zeolite.
- Ni/Y also enables lactate oxidation to pyruvate under atmospheric conditions.

## Abstract

Submarine hydrothermal vents harbor diverse microbial communities and have long intrigued researchers studying the origin of life. Transition metals in these environments can be reduced by serpentinization, potentially forming zeolite‐supported transition metal nanoparticles capable of driving prebiotic chemistry. This inorganic structure could catalyze biochemical reactions, including converting metabolically crucial pyruvate before the emergence of biological processes. This study explores the catalytic interconversion of pyruvate and lactate, mediated by lactate dehydrogenase in biochemical systems, using inorganic zeolite Y‐supported Ni nanoparticles (Ni/Y) under mild hydrothermal vent conditions. Our results demonstrate that Ni/Y effectively catalyzes the hydrogenation of pyruvate in an inert environment, facilitated by the in situ generation of H₂ through an autocatalytic reaction between Ni/Y and H₂O. Post‐reaction analysis by X‐ray absorption spectroscopy (XAS) revealed structural transformations in the catalyst, including the formation of unique nickel oxide and hydroxide species, along with extra‐framework aluminum from zeolite dealumination, resulting in a thin amorphous nickel oxide/hydroxide layer. Notably, Ni/Y also enables the oxidative reconversion of lactate to pyruvate under atmospheric conditions—an essential reaction catalyzed by lactate dehydrogenase in biological systems. These findings underscore the potential prebiotic role of Ni/Y, suggesting they may have catalyzed the synthesis of key metabolic intermediates.

Synthetic zeolite Y‐supported Ni mineral can catalyze the interconversion of metabolically crucial pyruvate and lactate under hydrothermal vent conditions, which could pave the way for the modern biological process by lactate dehydrogenase and nicotinamide adenine dinucleotide.