# Human Herpesvirus‐6 Infectious Meningitis With Lymphadenitis in an Immunocompetent Adult

## TL;DR

A case of HHV-6 causing meningitis and lymphadenitis in an otherwise healthy adult highlights the virus's potential as a pathogen in immunocompetent individuals.

## Contribution

This case report expands the understanding of HHV-6 as a possible cause of meningitis in immunocompetent adults.

## Key findings

- HHV-6 was detected in cerebrospinal fluid and lymphoid tissue using next-generation sequencing.
- The patient fully recovered after treatment with ganciclovir.
- The case suggests HHV-6 should be considered in diagnosing meningitis of unknown origin in immunocompetent individuals.

## Abstract

Human Herpesvirus 6 (HHV‐6) infections are primarily observed in immunocompromised individuals, such as those with acquired immunodeficiency syndrome or organ transplant recipients. However, its role as a pathogen in immunocompetent adults remains debated. We aimed to explore the clinical significance of HHV‐6 in immunocompetent individuals by presenting a case of HHV‐6‐associated meningitis with concurrent lymphadenitis.

We describe a case of an immunocompetent adult presenting with recurrent fever and headaches.

Diagnostic evaluations included next‐generation sequencing analysis identified HHV‐6 in both cerebrospinal fluid specimens and lymphoid tissue samples. The patient demonstrated complete clinical resolution following a 14‐day course of ganciclovir therapy.

This case underscores the need to consider HHV‐6 infection in immunocompetent adults presenting with meningitis of unknown etiology. Early detection and targeted antiviral therapy may lead to favorable clinical outcomes

Human Herpesvirus‐6 infectious meningitis with lymphadenitis in an immunocompetent adult.

CSF: cerebrospinal fluid; NGS: next‐generation sequencing; HHV‐6: Human herpes virus‐6