# Editorial: Senescence and reprogramming: hallmarks in aging and disease

**Authors:** F. Javier González-Rico, Jiyue Zhu, Guangyong Peng

PMC · DOI: 10.3389/fcell.2025.1622682 · Frontiers in Cell and Developmental Biology · 2025-05-16

## Full-text entities

- **Genes:** Klf4 (Kruppel-like transcription factor 4 (gut)) [NCBI Gene 16600] {aka EZF, Gklf, Zie}, Vdr (vitamin D (1,25-dihydroxyvitamin D3) receptor) [NCBI Gene 22337] {aka Nr1i1}, Sox2 (SRY (sex determining region Y)-box 2) [NCBI Gene 20674] {aka Sox-2, lcc, ysb}, Pou5f1 (POU domain, class 5, transcription factor 1) [NCBI Gene 18999] {aka NF-A3, Oct-3, Oct-3/4, Oct-4, Oct3, Oct3/4}
- **Diseases:** muscle injuries (MESH:D009135), age- (MESH:D019588), osteoporosis (MESH:D010024), retinal degeneration (MESH:D012162), cardiovascular diseases (MESH:D002318), myocardial infarction (MESH:D009203), genetic disorders (MESH:D030342), mitochondrial dysfunction (MESH:D028361), inflammation (MESH:D007249), diseases (MESH:D004194), neurodegenerative conditions (MESH:D019636), premature ovarian insufficiency (MESH:D016649), kidney and lung failure (MESH:D051437), progeroid syndomes (MESH:C536423), cancer (MESH:D009369), diabetes (MESH:D003920)
- **Chemicals:** ROS (-), 7-dehydrocholesterol (MESH:C016705), Vitamin D (MESH:D014807)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]

## Full text

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## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12123086/full.md

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Source: https://tomesphere.com/paper/PMC12123086