# Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus

## TL;DR

This study identifies radiological features linked to different gait patterns in patients with idiopathic normal pressure hydrocephalus.

## Contribution

The study reveals that the height of the third ventricle is a potential neuroimaging marker for the parkinsonian subtype of iNPH.

## Key findings

- The height of the third ventricle was significantly higher in the parkinsonian subtype of iNPH.
- Reduced callosal angle correlated with the severity of motor and urinary symptoms in iNPH patients.
- Radiological features may serve as useful markers for clinical monitoring of iNPH.

## Abstract

According to the higher-level gait disorder (HLGD) pattern, patients with idiopathic normal pressure hydrocephalus (iNPH) can be divided into two motor phenotypes; a disequilibrium (wide-based gait) subtype and a parkinsonian (locomotor) subtype. We aimed to understand the neuroimaging correlates of iNPH phenotyping into different gait patterns, by assessing specific radiological features and their correlations with clinical scores.

We enrolled 86 probable iNPH patients (53 males; age range: 69–88 years), who underwent a comprehensive clinical assessment, including neuropsychological tests, and a conventional MRI scan. The cohort was subdivided into disequilibrium subtype (29 subjects) and parkinsonian subtype of HLGD (57 patients) based on gait evaluation. We compared the iNPH subtypes assessing differences in eight linear radiological indexes and their clinical correlates.

The Height of the third ventricle was the only radiological feature that differed between the two motor phenotypes (p < 0.05), being higher in the parkinsonian subtype and showing a trend of correlation with the motor score of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale and with the continence score of the iNPH Rating Scale. Among several clinical-radiological correlations, a reduced callosal angle correlated with the severity of motor and urinary symptoms (p < 0.05).

A greater height of the third ventricle possibly leading to a top-down compressive effect on the midbrain could be a neuroimaging marker of the parkinsonian phenotype of iNPH. The extensive correlations between linear radiological indices and clinical scales suggest a potential role for radiological features in clinical monitoring.