# Construction and validation of a prediction model for early recurrence after catheter ablation in patients with persistent atrial fibrillation based on BNP, Ang Ⅱ, homocysteine, MHR, NLR

## TL;DR

This study builds a model to predict early recurrence of atrial fibrillation after ablation using biomarkers like BNP, Ang II, and blood ratios.

## Contribution

A novel nomogram model combining multiple biomarkers for predicting early recurrence after catheter ablation in persistent atrial fibrillation.

## Key findings

- The model showed good predictive accuracy with C-index values of 0.803 and 0.846 in training and verification sets.
- Key risk factors included diabetes, elevated BNP, homocysteine, MHR, NLR, and Ang II.
- The model's AUC values were 0.802 and 0.855 in training and verification sets, respectively.

## Abstract

To explore the feasibility and clinical value of early recurrence prediction model for persistent atrial fibrillation after catheter ablation based on brain natriuretic peptide (BNP), angiotensin Ⅱ(Ang Ⅱ), homocysteine, monocyte-to-high density lipoprotein cholesterol (MHR) and neutrophil-to-lymphocyte ratio (NLR).

279 patients with persistent atrial fibrillation who underwent catheter ablation in our hospital from January 2022 to December 2024 were divided into training group (n = 195) and verification group (n = 84) according to the ratio of 7:3. The risk factors were screened by univariate and multivariate Logistic regression analysis, and the nomogram model was constructed, and the effectiveness of the model was evaluated in the verification set.

Multivariate Logistic regression analysis showed that diabetes history, elevated BNP, homocysteine, MHR, NLR and Ang Ⅱ were independent risk factors for early postoperative recurrence (P < 0.05). The C-index index of the nomogram model in the training set and the verification set are 0.803 and 0.846, respectively, and the AUC under the ROC curve is 0.802 (95% CI: 0.685–0.918) and 0.855 (95% CI: 0.736–0.973), respectively.

The nomogram prediction model can well predict the early recurrence risk of patients with persistent atrial fibrillation after catheter ablation, and provide a reference for clinical individualized treatment, but it needs further verification by large sample and multi-center research.