# Coronary Stent-Induced Kounis Syndrome: A Case Report

**Authors:** Takuya Kakumoto, Hirofumi Kawamata, Masatoshi Hori, Kuniyasu Harimoto, Tatsuya Kawasaki

PMC · DOI: 10.7759/cureus.83208 · Cureus · 2025-04-29

## TL;DR

A man developed an allergic reaction and heart issues after a coronary stent, highlighting the need to consider metal allergies in such procedures.

## Contribution

This case report presents a rare instance of stent-induced Kounis syndrome and emphasizes the importance of allergy history in coronary interventions.

## Key findings

- A 54-year-old man developed anaphylaxis and chest pain after stent implantation.
- Emergency angiography revealed stent occlusion requiring repeated ballooning.
- The patient was found to have a metal allergy, linking it to Kounis syndrome.

## Abstract

Kounis syndrome is an acute coronary syndrome triggered by allergic hypersensitivity to various stimuli. Here, we report the case of a 54-year-old man who had coronary stent-induced type III Kounis syndrome. The patient developed a rash on the anterior chest wall and experienced throat discomfort 40 minutes after stent implantation in the left anterior descending artery. Given his history of allergies, a presumptive diagnosis of anaphylaxis was made, and 0.5 mg of adrenaline was injected intramuscularly into the left thigh. The patient's symptoms initially resolved; however, approximately 50 minutes after the onset of the allergic reaction, he developed chest pain accompanied by ST-segment elevation in the anterior leads. Emergency coronary angiography revealed total occlusion at the mid-portion of the distal stent implanted in the left anterior descending artery, which was treated with repeated ballooning. The patient was later found to have a metal allergy. This case highlights the importance of obtaining a thorough allergy history, particularly regarding metal allergies, and recognizing Kounis syndrome as a potential cause of stent thrombosis associated with allergic hypersensitivity during coronary interventions.

## Linked entities

- **Diseases:** anaphylaxis (MONDO:0100053)

## Full-text entities

- **Diseases:** allergic hypersensitivity (MESH:D004342), acute coronary syndrome (MESH:D054058), metal allergies (MESH:D013651), chest pain (MESH:D002637), anaphylaxis (MESH:D000707), rash (MESH:D005076), thrombosis (MESH:D013927), Kounis Syndrome (MESH:D000074962)
- **Chemicals:** adrenaline (MESH:D004837), Coronary Stent (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12122103/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12122103/full.md

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Source: https://tomesphere.com/paper/PMC12122103