# Bringing value to cancer research

**Authors:** Casey J. Allen, Horn M. Danea, Fabrice Smieliauskas, Stephen Edge, Rachel A. Greenup

PMC · DOI: 10.3389/fonc.2025.1580575 · Frontiers in Oncology · 2025-05-15

## TL;DR

This paper suggests expanding the definition of value in cancer trials to include patient experiences and costs, aiming for better, more patient-centered care.

## Contribution

A novel framework integrating oncologic outcomes, patient-reported outcomes, and cost analyses for value-based decision-making in cancer care.

## Key findings

- Current cancer trials often overlook patient-reported outcomes like quality of life and financial burden.
- A multidimensional visual tool, such as a radar chart, can support value-based shared decision-making.
- Standardizing value assessment could lead to more equitable and effective cancer care.

## Abstract

This article argues for incorporating a broader definition of “value” into cancer clinical trials. Current trials primarily focus on efficacy and safety, neglecting patient-reported outcomes (PROs) such as quality of life, financial toxicity, and time burden, as well as cost-effectiveness. We propose a novel framework integrating oncologic outcomes, PROs, and cost analyses. We also propose a multidimensional visual tool, such as a radar chart, to facilitate better-informed, value-based shared decision-making. This requires a collaborative approach, involving stakeholders in defining value metrics. While acknowledging challenges such as increased administrative burden and data interpretation complexities, a comprehensive framework can substantially improve patient-centered cancer care. The ultimate goal is to standardize value assessment in cancer research, leading to more equitable and effective care.

## Linked entities

- **Diseases:** cancer (MONDO:0004992)

## Full-text entities

- **Diseases:** toxicity (MESH:D064420), cancer (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12119247/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12119247/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12119247/full.md

---
Source: https://tomesphere.com/paper/PMC12119247