# Effect of orally administered cannabidiol oil on daily tonometric curve in healthy Italian Saddle horses

## TL;DR

This study shows that giving cannabidiol oil to healthy Italian Saddle horses significantly lowers their eye pressure for up to 8 hours.

## Contribution

The first study to demonstrate CBD's IOP-lowering effect in horses, suggesting potential use for glaucoma treatment.

## Key findings

- CBD 20% significantly reduced intraocular pressure in horses within 15 minutes of administration.
- The effect lasted for 8 hours, with IOP remaining significantly lower than baseline.
- CBD may serve as a hypotensive agent for managing glaucoma in horses.

## Abstract

Phytocannabinoids have the potential to lower intraocular pressure in both normal and glaucomatous eyes and they have been tested in different animal species, but not in the horse. The present paper describes the tonometric curve of healthy adult Italian Saddle horses after oral administration of cannabidiol oil (CBD).

CBD 20% was administered orally (oily solution) at the dose of 1 mg/kg to 8 adult horses and intraocular pressure (IOP) was evaluated by tonometric curve. Data were then compared to those of the same horses obtained the day before (blank) CBD administration.

15 minutes after CBD administration, IOP (time zero 27.3 ± 2.1 mmHg right eye; 24.6 ± 2.3 mmHg left eye) started to decrease (19.5 ± 5.2 mmHg right eye; 20.8 ± 2.4 mmHg left eye) and 1 hour later CBD it reached the minimum level in all horses (11.4 ± 7.5 mmHg right eye; 9.5 ± 5.8 mmHg left eye), remaining statistically significantly lower than normal values for the entire observation period (8 hours; 12.0 ± 7.9 mmHg right eye; 11.9 ± 7.8 mmHg left eye).

CBD 20% was effective to significantly reduce IOP in healthy adult Italian Saddle horses and may be an effective hypotensive agent to be implemented in case of primary or secondary glaucoma.