# Diagnostic Value of Peripheral Blood Smear Tests in Identifying Candida Infections in a Tertiary Care Setting: A Case Series

## TL;DR

This case series explores how peripheral blood smear tests can help detect Candida infections quickly and inexpensively, especially in hospitals with limited resources.

## Contribution

The study highlights the diagnostic potential of peripheral blood film tests as a rapid and cost-effective screening method for Candida infections.

## Key findings

- Budding yeasts were identified in peripheral blood films of three out of four patients with Candida infections.
- Peripheral blood film tests provided rapid preliminary insights, aiding early antifungal therapy initiation.
- Blood culture remains the gold standard, but PBF tests are a valuable initial screening tool in resource-limited settings.

## Abstract

Invasive fungal infections (IFIs) are a significant cause of morbidity and mortality in hospitalized patients, particularly among neonates and immunocompromised individuals. Candida species are one of the most commonly associated pathogens associated with IFIs. We present a case series of four patients with IFIs. All cases underwent peripheral blood film (PBF) examination, blood culture, and serum galactomannan testing. Budding yeasts were found in the PBF of three out of four cases. The findings were confirmed by culture. While blood culture remains the gold standard for diagnosing IFIs, the PBF test demonstrated its value as a rapid and cost-effective initial screening tool, especially in resource-limited settings. PBF tests can offer valuable preliminary insights, facilitating further diagnostic evaluation and early initiation of antifungal therapy. These findings underscore the potential utility of PBF tests in the early detection and management of IFIs.