# Limbal stem cell deficiency: a dreaded complication of chickenpox in children

**Authors:** Oumayma Elmansouri, Assia Lemkhoudem, Houda Bezza, Houssaine Ait Lhaj, Mohamed Kriet, Fouad Elasri

PMC · DOI: 10.1093/omcr/omaf037 · Oxford Medical Case Reports · 2025-05-28

## TL;DR

A child developed a rare eye condition called Limbal Stem Cell Deficiency after having chickenpox, highlighting the need for early detection and coordinated care.

## Contribution

This is the first reported case of Limbal Stem Cell Deficiency following chickenpox in a child.

## Key findings

- The child showed ocular symptoms like pain, redness, and photophobia two months after chickenpox.
- Ophthalmic examination revealed corneal neovascularization and conjunctivalization, indicating LSCD.
- Early recognition and collaboration between pediatricians and ophthalmologists are crucial for managing this condition.

## Abstract

We report a rare case of Limbal Stem Cell Deficiency (LSCD) in a 10-year-old child following chickenpox. The child presented with persistent ocular symptoms, including pain, redness, and photophobia, two months after the resolution of systemic chickenpox. Ophthalmic examination revealed conjunctival hyperemia, 360° conjunctivalization, corneal neovascularization, and an epithelial defect. LSCD, characterized by corneal neovascularization and conjunctivalization, can occur after viral infections, including herpes zoster. To our knowledge, this is the first reported case of LSCD following chickenpox in a child. Early recognition and collaborative care between pediatricians and ophthalmologists are essential for effective management.

## Linked entities

- **Diseases:** chickenpox (MONDO:0005700), Limbal Stem Cell Deficiency (MONDO:0025667)

## Full-text entities

- **Diseases:** viral infections (MESH:D014777), herpes zoster (MESH:D006562), pain (MESH:D010146), corneal neovascularization (MESH:D016510), epithelial defect (MESH:D009375), photophobia (MESH:D020795), LSCD (MESH:D000092423), conjunctival hyperemia (MESH:D003229), chickenpox (MESH:D002644)

## Full text

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## Figures

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## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12118088/full.md

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Source: https://tomesphere.com/paper/PMC12118088