# RETRACTION: lncRNA BZRAP1‐AS1 Alleviates Rheumatoid Arthritis by Regulating miR‐1286/COL5A2 Axis

PMC · DOI: 10.1002/iid3.70204 · Immunity, Inflammation and Disease · 2025-05-28

## TL;DR

This retracted paper claimed that a long non-coding RNA helps treat rheumatoid arthritis by regulating a specific gene pathway, but the findings are now considered unreliable.

## Contribution

The paper originally proposed a novel regulatory mechanism involving lncRNA BZRAP1-AS1 in rheumatoid arthritis.

## Key findings

- The paper claimed lncRNA BZRAP1-AS1 alleviates rheumatoid arthritis by regulating miR-1286/COL5A2.
- The study was retracted due to inconsistencies and unreliable conclusions.
- The authors did not respond to address concerns or provide original data.

## Abstract

RETRACTION: J. Zhu, S. Tu and Q. Qu, “lncRNA BZRAP1‐AS1 Alleviates Rheumatoid Arthritis by Regulating miR‐1286/COL5A2 Axis,” Immunity, Inflammation and Disease 10, no. 2 (2022): 163‐174, https://doi.org/10.1002/iid3.558.

The above article, published online on 11 November 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Marc Veldhoen; and John Wiley & Sons, Ltd. The retraction has been agreed upon due to inconsistencies and flaws identified in this article that affect the validity of the conclusions. The authors did not respond to address the concerns raised and did not provide their original data. The editors consider the results and conclusions reported in this article unreliable. The authors were informed of the retraction.

## Linked entities

- **Genes:** TSPOAP1-AS1 (TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1) [NCBI Gene 100506779], MIR1286 (microRNA 1286) [NCBI Gene 100302118], COL5A2 (collagen type V alpha 2 chain) [NCBI Gene 1290]
- **Diseases:** rheumatoid arthritis (MONDO:0008383)

## Full-text entities

- **Genes:** MIR1286 (microRNA 1286) [NCBI Gene 100302118] {aka MIRN1286, hsa-mir-1286, mir-1286}, TSPOAP1-AS1 (TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1) [NCBI Gene 100506779] {aka BZRAP1-AS1}, COL5A2 (collagen type V alpha 2 chain) [NCBI Gene 1290] {aka EDSC, EDSCL2}
- **Diseases:** Rheumatoid Arthritis (MESH:D001172), Inflammation (MESH:D007249)

## Full text

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Source: https://tomesphere.com/paper/PMC12117257