# Synthesis of pyrrolo[3,2-d]pyrimidine-2,4(3H)-diones by domino C–N coupling/hydroamination reactions

## TL;DR

This paper describes a new method to synthesize pyrrolo[3,2-d]pyrimidine-2,4(3H)-diones using a domino C–N coupling/hydroamination reaction, with their optical properties influenced by substitution patterns.

## Contribution

The novel contribution is the development of a domino C–N coupling/hydroamination reaction for synthesizing these compounds.

## Key findings

- The compounds were synthesized using a combination of Sonogashira reaction and domino C–N coupling/hydroamination.
- The optical properties of the compounds depend on their substitution patterns.

## Abstract

A variety of pyrrolo[3,2-d]pyrimidine-2,4(3H)-diones were prepared by a combination of Sonogashira reaction and subsequent cyclization by domino C–N coupling/hydroamination reaction. The optical properties (UV–vis absorption and fluorescence) depend on the substitution pattern of the compounds.