# A convergent synthetic approach to the tetracyclic core framework of khayanolide-type limonoids

## TL;DR

This paper presents a new method to build the complex tetracyclic core of khayanolide-type limonoids in a controlled and efficient way.

## Contribution

The paper introduces a novel convergent synthetic strategy for constructing the tetracyclic core of khayanolide-type limonoids with enantioselectivity.

## Key findings

- The method uses acylative kinetic resolution of a benzylic alcohol as a key step.
- A 1,2-Grignard addition and an AcOH-interrupted Nazarov cyclization complete the tetracyclic core formation.
- The approach provides an advanced intermediate with high stereochemical control.

## Abstract

A convergent approach for the enantioselective construction of an advanced intermediate containing the [5,5,6,6]-tetracyclic core framework of the khayanolide-type limonoids was described. The strategy features an acylative kinetic resolution of the benzylic alcohol, a 1,2-Grignard addition and an AcOH-interrupted Nazarov cyclization.