Correction: Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study

Abstract

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Correction: Journal of Neurology (2024) 271:7250–7263 10.1007/s00415-024-12608-6

In the original version of this article, author’s name Filippo Martinelli Boneschi was incorrectly written as Filippo Giovanni Martinelli Boneschi.

In Table 2, first two columns were missing. The Table 2 which previously appeared as Table 2. List of top-associated variants after meta-analysis. The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10^–5^. The effect allele is the minor allelePositionMinor alleleMajor alleleMAFPORSEI^2^GeneGenomic contextDistance to gene187,410,850TC0.2681.328E−060.5820.1120F11-AS1ncRNA_intronic68,071,570TC0.4211.678E−061.5380.0900PIGH; ARG2IntergenicDist = 4552; Dist = 15,067111,037,829TA0.2512.793E−060.5960.11113KLF4; ACTL7BIntergenicDist = 785,779; Dist = 579,04020,863,249GA0.0574.804E−062.1220.1650GJB6; CRYL1IntergenicDist = 56,715; Dist = 114,55798,275,102CG0.4296.938E−060.6500.09634LOC101927310; LINC00923IntergenicDist = 171,174; Dist = 10,74447,775,385AG0.2301.187E−051.5610.1020SEMA6DIntronic21,728,917AG0.1421.191E−050.5100.1540ZNF385DIntronic187,402,360AG0.4801.233E−051.4960.0920F11-AS1ncRNA_intronic115,392,100AG0.3471.259E−051.4760.0890GAP43Intronic12,783,519TC0.0751.325E−051.9340.1510LINC00681; TRMT9BIntergenicDist = 107,719; Dist = 19,66343,181,587TC0.0801.362E−051.9180.1500A4GALT; ARFGAP3IntergenicDist = 64,280; Dist = 10,92279,303,163GA0.4301.475E−051.4690.0890WWOX; MAFIntergenicDist = 56,599; Dist = 324,57298,347,870CG0.4291.494E−050.6760.09157LINC00923ncRNA_intronic27,204,531CT0.0952.087E−051.7750.13542ABI1; FAM238CIntergenicDist = 54,515; Dist = 15,60447,746,678CG0.0752.692E−051.8390.14529STILExonic113,293,608GA0.4112.744E−051.4610.0900TUBGCP3; ATP11AUNIntergenicDist = 51,109; Dist = 7750606,173CA0.1432.862E−051.6460.1190B4GALNT3Intronic83,766,280AC0.1142.909E−051.7390.13248DLG2Intronic236,647,736TC0.2332.939E−051.4950.0960EDARADDUTR3NM_145861:c.1787C>T; NM_080738:c.1787C>T93,450,212AG0.2953.023E−051.4710.0930RUNX1T1; LOC102724710IntergenicDist = 334,599; Dist = 127,4594,314,917AG0.2203.087E−051.5230.1010CSMD1Intronic81,279,746AG0.2713.116E−051.4790.0946.4SPRY2; LINC00377IntergenicDist = 364,485; Dist = 312,780111,023,899TC0.4043.369E−051.4410.0880KLF4; ACTL7BIntergenicDist = 771,849; Dist = 592,970189,243,943TC0.4133.424E−051.4330.0870TPRG1; TP63IntergenicDist = 200,850; Dist = 70,592114,813,313CT0.2673.459E−051.4830.0950TBX5Intronic110,446,839GA0.4133.508E−051.4330.0870IRS2; LINC00396IntergenicDist = 7909; Dist = 258,793177,987,660GA0.1373.639E−051.6170.1160CRYZL2PncRNA_intronic31,271,788AG0.0723.733E−051.8450.14860OVOS2ncRNA_intronic206,468,850TG0.4194.007E−051.4330.0880PARD3BIntronic54,692,961GA0.1164.025E−051.6520.1226.9TINAG; FAM83BIntergenicDist = 438,021; Dist = 18,608141,938,633CT0.0694.217E−051.8900.15574MGAM2; MOXD2PIntergenicDist = 16,509; Dist = 192381,959,114TC0.4994.222E−050.6970.0885.8ATP6AP1L; MIR3977IntergenicDist = 343,363; Dist = 176,860158,058,545TC0.4364.257E−051.4550.0920ZDHHC14Intronic180,648,923CT0.4804.571E−050.6990.0880LINC01098; LINC00290IntergenicDist = 1,737,019; Dist = 1,336,32083,182,354AG0.2994.605E−051.4580.0930DLG2Intronic10,732,844GA0.0504.841E−052.0530.17753TEKT5Intronic130,499,623GA0.0964.929E−051.7490.13842LINC01163; LINC02667IntergenicDist = 383,633; Dist = 211,474156,675,608AC0.1354.934E−051.6420.1220GUCY1A1; GUCY1B1IntergenicDist = 17,399; Dist = 456550,679,081TG0.3724.966E−051.4480.0910DEFB112; TFAP2DIntergenicDist = 661,439; Dist = 2158For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotationAbbreviations: MAF (Minor Allele Frequency), P (p value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I^2^ (heterogeneity index)

but Table 2 should have appeared as shown below. Table 2. List of top associated variants after meta-analysisSNPChromosomePositionMinor alleleMajor alleleMAFPORSEI^2^GeneGenomic contextDistance to geners111324004187410850TC0.2681.328E−060.5820.1120F11-AS1ncRNA_intronicrs128852611468071570TC0.4211.678E−061.5380.0900PIGH; ARG2Intergenicdist = 4552; dist = 15,067rs13233749111037829TA0.2512.793E−060.5960.11113KLF4; ACTL7BIntergenicdist = 785,779; dist = 579,040rs611664791320863249GA0.0574.804E−062.1220.1650GJB6; CRYL1Intergenicdist = 56,715; dist = 114,557rs10329541598275102CG0.4296.938E−060.6500.09634LOC101927310; LINC00923Intergenicdist = 171,174; dist = 10,744rs757728841547775385AG0.2301.187E−051.5610.1020SEMA6DIntronicrs34736466321728917AG0.1421.191E−050.5100.1540ZNF385DIntronicrs126498864187402360AG0.4801.233E−051.4960.0920F11-AS1ncRNA_intronicrs130737593115392100AG0.3471.259E−051.4760.0890GAP43Intronicrs2977141812783519TC0.0751.325E−051.9340.1510LINC00681; TRMT9BIntergenicdist = 107,719; dist = 19,663rs72868222243181587TC0.0801.362E−051.9180.1500A4GALT; ARFGAP3Intergenicdist = 64,280; dist = 10,922rs99223301679303163GA0.4301.475E−051.4690.0890WWOX; MAFIntergenicdist = 56,599; dist = 324,572rs727526041598347870CG0.4291.494E−050.6760.09157LINC00923ncRNA_intronicrs18153231027204531CT0.0952.087E−051.7750.13542ABI1; FAM238CIntergenicdist = 54,515; dist = 15,604rs10789505147746678CG0.0752.692E−051.8390.14529STILExonicrs957782413113293608GA0.4112.744E−051.4610.0900TUBGCP3; ATP11AUNIntergenicdist = 51,109; dist = 7750rs215960012606173CA0.1432.862E−051.6460.1190B4GALNT3Intronicrs128061601183766280AC0.1142.909E−051.7390.13248DLG2Intronicrs64289551236647736TC0.2332.939E−051.4950.0960EDARADDUTR3NM_145861:c.1787C > T; NM_080738:c.1787C > Trs1072934893450212AG0.2953.023E−051.4710.0930RUNX1T1; LOC102724710Intergenicdist = 334,599; dist = 127,459rs121768084314917AG0.2203.087E−051.5230.1010CSMD1Intronicrs124280951381279746AG0.2713.116E−051.4790.0946.4SPRY2; LINC00377Intergenicdist = 364,485; dist = 312,780rs107392559111023899TC0.4043.369E−051.4410.0880KLF4; ACTL7BIntergenicdist = 771,849; dist = 592,970rs68038443189243943TC0.4133.424E−051.4330.0870TPRG1; TP63Intergenicdist = 200,850; dist = 70,592rs796039612114813313CT0.2673.459E−051.4830.0950TBX5Intronicrs141431913110446839GA0.4133.508E−051.4330.0870IRS2; LINC00396Intergenicdist = 7909; dist = 258,793rs75375681177987660GA0.1373.639E−051.6170.1160CRYZL2PncRNA_intronicrs1124170831231271788AG0.0723.733E−051.8450.14860OVOS2ncRNA_intronicrs130317932206468850TG0.4194.007E−051.4330.0880PARD3BIntronicrs9475026654692961GA0.1164.025E−051.6520.1226.9TINAG; FAM83BIntergenicdist = 438,021; dist = 18,608rs598010307141938633CT0.0694.217E−051.8900.15574MGAM2; MOXD2PIntergenicdist = 16,509; dist = 1923rs10040233581959114TC0.4994.222E−050.6970.0885.8ATP6AP1L; MIR3977Intergenicdist = 343,363; dist = 176,860rs6188236158058545TC0.4364.257E−051.4550.0920ZDHHC14Intronicrs44448754180648923CT0.4804.571E−050.6990.0880LINC01098; LINC00290Intergenicdist = 1,737,019; dist = 1,336,320rs20680761183182354AG0.2994.605E−051.4580.0930DLG2Intronicrs766744641610732844GA0.0504.841E−052.0530.17753TEKT5Intronicrs1226503410130499623GA0.0964.929E−051.7490.13842LINC01163; LINC02667Intergenicdist = 383,633; dist = 211,474rs68388764156675608AC0.1354.934E−051.6420.1220GUCY1A1; GUCY1B1Intergenicdist = 17,399; dist = 4565rs1923523650679081TG0.3724.966E−051.4480.0910DEFB112; TFAP2DIntergenicdist = 661,439; dist = 2158The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10^−5^. The effect allele is the minor alleleFor each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotationMAF (Minor Allele Frequency), P (p-value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I^2^ (heterogeneity index)