Corrigendum: Gatifloxacin hydrochloride confers broad-spectrum antibacterial activity against phytopathogenic bacteria
Yanxia Huang, Bin Peng, Chenhui Li, Yuqin Wu, Zixian Zeng, Moh Tariq, Lin Jiang, Shun-xiang Li, Dousheng Wu
Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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TopicsNephrotoxicity and Medicinal Plants · Antibiotics Pharmacokinetics and Efficacy · Antibiotic Resistance in Bacteria
In the published article, there was an error in the legend for Figure 1, page 4 as published. The compound library composition was inaccurately described as exclusively containing 58 microorganism-derived natural products, whereas it included 57 microorganism-derived small molecules and 1 fully synthetic compound. The corrected legend appears below.
“Screening of microorganism-derived and synthetic compounds against R. solanacearum. The effects of 57 microorganism-derived small molecules and 1 fully synthetic compound on the growth of R. solanacearum were investigated.”
In the published article, there was an error. The source of the fully synthetic compounds was incorrectly described as “microorganism-derived compounds” in the text.
A correction has been made to Abstract Section, page 1, paragraph 1. This sentence previously stated:
“In this study, we screened a library of 58 microorganism-derived natural products for their antibacterial activity against R. solanacearum.”
The corrected sentence appears below:
“In this study, we screened a library of 57 microorganism-derived small molecule compounds and 1 fully synthetic small molecule compound for their antibacterial activity against R. solanacearum.”
A correction has been made to Abstract Section, page 1, paragraph 1. This sentence previously stated:
“In summary, our results demonstrate the great potential of microorganism-derived compounds as broad-spectrum antibacterial compounds, providing alternative ways for the efficient control of bacterial plant diseases.”
The corrected sentence appears below:
“In summary, our results demonstrate the great potential of microorganism-derived and synthetic small molecules as broad-spectrum antibacterial compounds, providing alternative ways for the efficient control of bacterial plant diseases.”
A correction has been made to Introduction Section, page 2, paragraph 5. This sentence previously stated:
“Gatifloxacin hydrochloride is a microorganism-derived compound with promising antibacterial activities against both Gram positive and Gram-negative bacteria, including some anaerobic organisms and mycobacteria.”
The corrected sentence appears below:
“Gatifloxacin hydrochloride is a fully synthetic small molecule with promising antibacterial activities against both Gram positive and Gram-negative bacteria, including some anaerobic organisms and mycobacteria.”
A correction has been made to Introduction Section, page 2, paragraph 6. This sentence previously stated:
“In this study, we screened a microorganism-derived compound library to identify compounds that show good antibacterial activity against R. solanacearum.”
The corrected sentence appears below:
“In this study, we screened a compound library comprising 57 microorganism-derived compounds and 1 fully synthetic compound to identify compounds that show good antibacterial activity against R. solanacearum.”
A correction has been made to Materials and methods Section, Microorganism-derived compounds information, page 2. This heading previously stated:
“Microorganism-derived compounds information.”
The corrected heading appears below:
“Small molecule compounds information.”
A correction has been made to Materials and methods Section, Microorganism-derived compounds information, page 2, paragraph 1. This sentence previously stated:
“In this study, all microorganism-derived compounds (HPLC purity >99%) were acquired from TargetMol.”
The corrected sentence appears below:
“In this study, all small molecule compounds (HPLC purity >99%) were acquired from TargetMol.”
A correction has been made to Results Section, A screen identifies gatifloxacin hydrochloride as a novel antibacterial agent against Ralstonia solanacearum, page 4, paragraph 1. This sentence previously stated:
“To further identify natural compounds that can inhibit R. solanacearum growth, we screened a library consisting of 58 microorganism-derived compounds and tested their antibacterial activity against R. solanacearum at a concentration of 10 μM.”
The corrected sentence appears below:
“To further identify natural compounds that can inhibit R. solanacearum growth, we screened a library consisting of 57 microorganism-derived small molecule compounds and 1 fully synthetic small molecule compound and tested their antibacterial activity against R. solanacearum at a concentration of 10 μM.”
A correction has been made to Results Section, A screen identifies gatifloxacin hydrochloride as a novel antibacterial agent against Ralstonia solanacearum, page 4, paragraph 1. This sentence previously stated:
“In summary, the screening identified several microorganism-derived natural compounds as novel antibacterial agents against R. solanacearum.”
The corrected sentence appears below:
“In summary, the screening identified several small molecule compounds as novel antibacterial agents against R. solanacearum.”
A correction has been made to Results Section, Gatifloxacin hydrochloride delays bacterial wilt disease development, page 5, paragraph 1. This sentence previously stated:
“Given that gatifloxacin hydrochloride shows strong antibacterial activity against R. solanacearum and reduces biofilm formation, we hypothesized that this microorganism-derived compound could delay bacterial wilt disease development caused by this pathogen. R. solanacearum has a wide range of host plants, with Solanaceae plants, particularly tomato, being the most common hosts.”
The corrected sentence appears below:
“Given that gatifloxacin hydrochloride shows strong antibacterial activity against R. solanacearum and reduces biofilm formation, we hypothesized that this small molecule compound could delay bacterial wilt disease development caused by this pathogen. R. solanacearum has a wide range of host plants, with Solanaceae plants, particularly tomato, being the most common hosts.”
A correction has been made to Discussion Section, page 8, paragraph 2. This sentence previously stated:
“As a microorganism-derived natural compound, gatifloxacin hydrochloride is relatively safe and environmentally friendly.”
The corrected sentence appears below:
“As a small molecule compound, gatifloxacin hydrochloride is relatively safe and environmentally friendly.”
A correction has been made to Discussion Section, paragraph 5. This sentence previously stated:
“As gatifloxacin hydrochloride originates from microbial sources, these discoveries reinforce the notion that compounds derived from microorganisms hold significant promise as a versatile antibacterial for combating plant-based infections.”
The corrected sentence appears below:
“As gatifloxacin hydrochloride is a small-molecule compound, these discoveries reinforce the notion that small-molecule compounds hold significant promise as versatile antibacterials for combating plant-based infections.”
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.