# The Sibylline Relationship Between Human Papillomavirus and Endometrial Cancer: Scarcity of Strong Evidence Linking Both Conditions

## TL;DR

This review examines the limited evidence linking human papillomavirus (HPV) to endometrial cancer, despite its role in other cancers.

## Contribution

The paper provides a critical review of existing studies on the potential relationship between HPV and endometrial cancer.

## Key findings

- HPV is strongly linked to cervical and other cancers but not conclusively to endometrial cancer.
- Current studies show a scarcity of strong evidence supporting a direct role of HPV in endometrial carcinogenesis.
- More research is needed to clarify the potential connection between HPV and endometrial cancer.

## Abstract

Endometrial cancer (EC) is the fourth-most frequent cancer among the female population and a leading cause of death. Multiple factors are susceptible to causing tumorigenesis, including obesity, lack of physical activity, diabetes mellitus, high concentration of estrogen during menopause, unopposed exposure to estrogen, duration of menses, nulliparity and infertility. Human papillomavirus (HPV) is a double-stranded DNA virus, with certain genotypes exclusively human. HPV plays a major role in some cancers (cervical cancer, head and neck cancer, lung cancer, and anogenital cancers). Given the intricate correlation between HPV and cervical cancer, the scientific community conjectured that HPV may be implicated in the carcinogenesis of the endometrium. In this review, we will direct our interest towards previous studies that focused on the expression of HPV on EC samples and cover how both conditions might connect to each other.