# The Association Between Maternal Urinary Iodine Concentration and Neonatal Anthropometry

## TL;DR

This study found no link between a mother's iodine levels during pregnancy and the size of her newborn baby.

## Contribution

The study provides new evidence that maternal urinary iodine concentration does not correlate with neonatal anthropometric outcomes.

## Key findings

- No significant association was found between maternal urinary iodine concentration and neonatal birth weight, length, or head circumference.
- Stratified analysis by fetal sex also showed no significant associations.
- The study suggests further research is needed to explore maternal iodine effects on neonatal outcomes.

## Abstract

Background/Objectives: Iodine deficiency disorders remain a global public health concern, as acknowledged by the World Health Organization (WHO). Adequate maternal iodine intake during pregnancy is essential for normal fetal development, yet the relationship between maternal iodine status and fetal growth remains controversial. Urinary Iodine Concentration (UIC) is a commonly used marker for assessing iodine status. This study evaluates the association between maternal UIC and neonatal anthropometric parameters. Methods: This prospective single-center cohort study included 202 pregnant women without known or reported thyroid disease, recruited between 2018 and 2021. Maternal iodine status was assessed by UIC from spot urine samples collected at the time of recruitment. Correlations were analyzed between maternal UIC and neonatal anthropometric measures, including birth weight (g), length (cm), and head circumference (cm). Analyses stratified by fetal sex were also performed. Results: No statistically significant association was found between UIC and neonatal anthropometric measures. Analysis of these correlations, stratified by fetal sex, did not reveal any statistically significant associations either. Conclusions: Maternal UIC showed no association with neonatal anthropometric outcomes in this study, regardless of fetal sex. Further research is needed to investigate the additional effects of maternal iodine status in healthy, euthyroid pregnant women on neonatal outcomes.