# Successful Management of Spondylodiscitis Caused by Aspergillus nidulans: A Case Report and Literature Review

**Authors:** Safia Nadji, Nicolas Ettahar, Jordan Leroy, Gisèle Dewulf, Edith Mazars

PMC · DOI: 10.3390/jof11050361 · Journal of Fungi · 2025-05-06

## TL;DR

This paper presents a rare case of spinal infection caused by a fungus called Aspergillus nidulans and successfully treated with voriconazole.

## Contribution

The novelty lies in reporting a rare case of spondylodiscitis caused by Aspergillus nidulans in an immunocompromised patient.

## Key findings

- A 59-year-old immunocompromised patient was diagnosed with spondylodiscitis caused by Aspergillus nidulans.
- The patient was successfully treated with voriconazole, highlighting its effectiveness for this rare infection.
- The case emphasizes the importance of early diagnosis and treatment in immunocompromised individuals.

## Abstract

We report a case of spondylodiscitis caused by Aspergillus nidulans (SCAN). A. nidulans is a saprophytic fungus and emerging pathogen responsible for a variety of infections, although it is rarely implicated in osteoarticular infections. The patient was a 59-year-old immunocompromised patient with a history of lymphoma and splenectomy. Following diagnosis, the patient was promptly and effectively treated with voriconazole. A literature review underlines the distinctive features of the few case reports of SCAN, as well as the original features of the present case report.

## Linked entities

- **Chemicals:** voriconazole (PubChem CID 71616)
- **Diseases:** lymphoma (MONDO:0003659)
- **Species:** Aspergillus nidulans (taxon 162425)

## Full-text entities

- **Diseases:** infections (MESH:D007239), Spondylodiscitis (MESH:D015299), osteoarticular infections (MESH:D014394), lymphoma (MESH:D008223)
- **Chemicals:** voriconazole (MESH:D065819)
- **Species:** Methanobacterium alkalithermotolerans (species) [taxon 2731220], Homo sapiens (human, species) [taxon 9606], Aspergillus nidulans (species) [taxon 162425]

## Full text

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## Figures

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## References

27 references — full list in the complete paper: https://tomesphere.com/paper/PMC12112710/full.md

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Source: https://tomesphere.com/paper/PMC12112710