# Optimizing Imaging Techniques for Left Atrial Appendage Closure: Insights and Emerging Directions

**Authors:** Valentina Barletta, Mattia Alberti, Riccardo Agostini, Fausto Pizzino, Giancarlo Trimarchi, Maria Grazia D’Alfonso, Marco Solari, Giulio Zucchelli, Alberto Cresti

PMC · DOI: 10.3390/jcm14103607 · Journal of Clinical Medicine · 2025-05-21

## TL;DR

This paper reviews how imaging techniques can be optimized to improve left atrial appendage closure procedures for patients with atrial fibrillation.

## Contribution

The paper emphasizes the role of imaging specialists in enhancing patient selection and procedural success for LAAC.

## Key findings

- Imaging specialists play a crucial role in LAAC procedures.
- A multidisciplinary approach improves patient outcomes in LAAC.
- Optimized imaging techniques can enhance procedural success and long-term efficacy.

## Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults and is associated with significant morbidity and mortality, including an increased risk of stroke, heart failure, dementia, and recurrent hospitalizations. As life expectancy rises, both the incidence and prevalence of AF continue to grow. Stroke prevention remains a cornerstone of AF management, with oral anticoagulation being the primary strategy to reduce thromboembolic risk. However, despite their advantages, direct oral anticoagulants do not completely eliminate the risk of bleeding complications. For patients in whom anticoagulation is contraindicated, poorly tolerated, or ineffective at preventing AF-related stroke, interventional alternatives have gained traction. The left atrial appendage (LAA), a primary site of thrombus formation in AF, can be occluded through a catheter-based procedure known as left atrial appendage closure (LAAC) or left atrial appendage occlusion (LAAO). This review aims to provide imaging specialists with a comprehensive understanding of their role in LAAC, underscoring the importance of a multidisciplinary approach to enhance patient selection, procedural success, and long-term efficacy.

## Linked entities

- **Diseases:** atrial fibrillation (MONDO:0004981), stroke (MONDO:0005098), heart failure (MONDO:0005252), dementia (MONDO:0001627)

## Full-text entities

- **Diseases:** thromboembolic (MESH:D013923), LAAO (MESH:D059446), cardiac arrhythmia (MESH:D001145), Stroke (MESH:D020521), heart failure (MESH:D006333), AF (MESH:D001281), thrombus (MESH:D013927), dementia (MESH:D003704), bleeding (MESH:D006470)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12112684/full.md

## References

90 references — full list in the complete paper: https://tomesphere.com/paper/PMC12112684/full.md

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Source: https://tomesphere.com/paper/PMC12112684