# Hematologic Indices and Global Registry of Acute Coronary Events (GRACE) Risk Score in Acute Coronary Syndrome Patients in Ethiopia

## TL;DR

This study explores how blood-related measurements like red cell distribution width and mean platelet volume are linked to risk scores in patients with heart attacks in Ethiopia.

## Contribution

The study identifies RDW and MPV as independent predictors of higher GRACE risk scores in acute coronary syndrome patients.

## Key findings

- Higher RDW and MPV were significantly correlated with worse GRACE risk scores.
- RDW and MPV were confirmed as independent predictors of increased GRACE risk scores in multivariable analysis.

## Abstract

Prognostic ratings are essential for making quick clinical decisions. In patients with acute coronary syndrome (ACS), the Global Registry of Acute Coronary Events (GRACE) score is often used to predict in-hospital mortality. Hematological indices are strongly correlated with the likelihood of adverse outcomes in ACS patients, given the systemic hypoxemia and inflammation linked to its pathophysiology. This study aimed to assess the relationship between hematologic indices and the GRACE risk score in ACS patients.

We consecutively recruited patients diagnosed with ACS at Jimma Medical Center (JMC) from May 1, 2022, to October 31, 2023. We performed biochemical analyses and complete blood counts, calculating GRACE scores. We correlated two continuous parameters and evaluated GRACE risk score independent predictors using multivariate linear regression analysis.

A total of 110 patients were included, with 74 (67.3%) being men. The mean age was 56 (±11) years. Significant correlations were found between red cell distribution width (RDW), mean platelet volume (MPV), plateletcrit, and platelet count with worse GRACE risk scores (r = 0.569, P <r = 0.585, P < 0.001; r = 0.400, P < 0.001; r = 0.274, P < 0.013, respectively). In multivariable linear regression, higher RDW and MPV were associated with higher GRACE risk scores.

This study revealed significant differences in hematologic parameters among ACS patients with varying GRACE risk scores. Increased RDW and MPV were identified as independent predictors for high GRACE risk scores.