# Bilateral Wilms Tumour: Is Neoadjuvant Doxorubicin Necessary?

## TL;DR

This paper examines whether neoadjuvant doxorubicin is necessary in treating bilateral Wilms tumour, comparing treatment protocols and outcomes between North America and Europe.

## Contribution

The paper provides a comparative analysis of treatment protocols and evaluates the role of doxorubicin in bilateral Wilms tumour management.

## Key findings

- Both COG and SIOP protocols recommend surgical resection at week 6 or 12.
- Doxorubicin's impact on tumour response and patient outcomes remains unclear and variable.
- Doxorubicin is associated with long-term cardiotoxic effects in survivors.

## Abstract

Approximately 5% to 8% of patients with Wilms tumour have bilateral disease. The prevalence of bilateral Wilms tumour (BWT) is higher in individuals with genetic predisposition syndromes than in those without. The goal of therapy is to preserve as much renal tissue as possible without compromising the overall oncological outcomes, utilising neoadjuvant chemotherapy followed by nephron sparing surgery (NSS) if possible. The Children’s Oncology Group (COG) in North America and the International Society of Paediatric Oncology (SIOP) in Europe have developed the main protocols for the treatment of BWT. Both protocols are similar: initial biopsies are not indicated, and they both recommend surgical resection at week 6 or no later than week 12. Chemotherapy includes the use of vincristine and actinomycin-D in both protocols, but the COG approach also includes the use of doxorubicin, which is a cardiotoxic drug with important long-term effects on the cardiac function of childhood cancer survivors. What doxorubicin adds to patients with BWT in terms of radiological tumour response, resectability, long-term renal function and overall survival, is still not very well described and it may be variable depending on the tumour biology. This article describes the current approach for BWT in North America and Europe, focusing on the potential effect that doxorubicin may have on patient outcomes.