# Approaches to Reduce Toxicity in Pediatric Brain Tumors

## TL;DR

This paper discusses ways to reduce long-term treatment side effects in children with brain tumors by adapting therapies and using supportive care.

## Contribution

The paper highlights risk-adapted treatment strategies and de-escalation to minimize late effects in pediatric CNS tumor survivors.

## Key findings

- Treatment techniques and risk-adapted approaches help reduce long-term toxicity.
- De-escalation of therapy when feasible can minimize late effects in survivors.
- Supportive therapy and surveillance are crucial for managing treatment-related complications.

## Abstract

Pediatric central nervous system (CNS) tumor survivors are highly susceptible to long-term toxicity due to tumor location and also the treatment received. Advancements in treatment techniques, risk-adapted approaches to therapy with adjustments to treatment regimens—including de-escalation when feasible—along with the addition of supportive therapy and surveillance in these survivors, serve to minimize and manage late effects of therapy.