# Solid-State Nanopore Readout of Programmable DNA and Peptide Nanostructures for Scalable Digital Data Storage

## TL;DR

This paper introduces a new method for storing digital data using DNA and peptide nanostructures, read via solid-state nanopores, offering scalable and secure biological data storage.

## Contribution

The paper introduces novel DNA and peptide nanostructure synthesis methods and encoding schemes for scalable, secure data storage using solid-state nanopores.

## Key findings

- Solid-state nanopores enable scalable and inexpensive reading of DNA and peptide nanostructures.
- Peptide nanostructures via click-chemistry expand encoding sources and add functionalities for encryption and formatting.
- A comprehensive framework for data management, including encryption, decryption, and erasure, is presented.

## Abstract

DNA information storage holds tremendous potential due to its scalability, long lifespan, and environmental sustainability. The synthesis and reading of complex DNA data structures are of central importance. In this work, we propose new encoding schemes through novel synthesis methods of DNA and peptide nanostructures. Silicon nitride (SiNx) solid-state nanopores (ssNPs) are employed as the detection platform to enable scalable and inexpensive reading. This approach is no longer constrained by the limitations of single-base sequencing technologies. Peptide nanostructures are introduced as a data medium via click-chemistry, expanding encoding sources. By integrating a photosensitive PC-linker, this approach endows the data chain with functionalities for encryption and data formatting, enhancing the security and organization of biological information storage. Our study presents a comprehensive framework for data management from data synthesis to post-processing, which includes encryption, decryption, and erasure functionalities.