Correction: Kim et al. Novel Gene Polymorphisms for Stable Warfarin Dose in a Korean Population: Genome-Wide Association Study. Biomedicines 2023, 11, 2308
Jung Sun Kim, Sak Lee, Jeong Yee, Kyemyung Park, Eun Jeong Jang, Byung Chul Chang, Hye Sun Gwak
Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsPharmacogenetics and Drug Metabolism · Hormonal Regulation and Hypertension · Eicosanoids and Hypertension Pharmacology
Text Correction
There was an error in the original publication [1]. We applied a relaxed p-value threshold of 5 × 10^−7^, which was mentioned in the Results section. However, this threshold was not stated in the Abstract and Conclusions sections, which may mislead readers into assuming that the conventional genome-wide significance threshold (5 × 10^−8^) was used.
A correction has been made to the Abstract:
GWAS was performed with a lenient threshold of 5 × 10^−7^ to identify associations between genotypes and the warfarin maintenance dose, by comparing the allele frequency of genetic variants between individuals.
A correction has been made to the Conclusions:
Our GWAS has uncovered three previously unreported genetic variants (FRAS1 rs4386623, FAM201A rs1890109, and NKX2-6 rs310279) that demonstrate associations at a relaxed significance threshold with stable warfarin dose requirements in heart valve replacement patients.
The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
The reference list from the paper itself. Each links out to its DOI / PubMed record.