# Strategies for Anticancer Treatment in p53-Mutated Head and Neck Squamous Cell Carcinoma

## TL;DR

This paper reviews six treatment strategies for head and neck cancer with p53 mutations, aiming to inspire new cancer therapies.

## Contribution

The paper introduces six novel therapeutic strategies targeting p53 mutations in head and neck cancer.

## Key findings

- Six strategies for treating p53-mutated HNSCC are summarized, including reactivation and degradation of p53.
- HNSCC has a high p53 mutation rate, making these strategies potentially applicable to other cancers with similar mutations.
- Factors influencing the effectiveness of anticancer therapies in p53-mutated HNSCC are explored.

## Abstract

This Opinion summarizes the strategies for anticancer treatment in p53-mutated head and neck squamous cell carcinoma (HNSCC). It examines six strategies for anticancer treatment in p53-mutated HNSCC: 1. direct reactivation of mutated p53; 2. activation of p63; 3. activation of p73; 4. degradation of mutated p53; 5. blocking the p53-regulated oncogenic microRNA; and 6. blocking the p53-regulated oncogenic long non-coding RNA. Since HNSCC has a high p53 mutation rate compared to other types of cancers, these strategies for combating p53-mutated HNSCC may prove useful for generating new ideas or methods for developing treatments for other cancers with p53 mutations. This article also explores other factors that may impact the effectiveness of anticancer therapies in p53-mutated HNSCC.