# Cardiac metastasis in papillary thyroid carcinoma: a case report and literature review

## TL;DR

A rare case of papillary thyroid carcinoma metastasizing to the heart is reported, highlighting the aggressive nature of the disease and the need for awareness of unusual metastatic sites.

## Contribution

This case report adds to the limited literature on cardiac metastasis in papillary thyroid carcinoma and emphasizes its aggressive clinical course.

## Key findings

- A patient with papillary thyroid carcinoma developed cardiac metastasis after initial treatment and lung metastasis.
- Cardiac metastasis from thyroid cancer is rare and often leads to rapid clinical deterioration.
- The case highlights the importance of considering atypical metastatic sites in advanced thyroid cancer.

## Abstract

Metastasis of malignant tumors to the heart is rare in clinical practice, particularly in papillary thyroid carcinoma (PTC). This report presents the case of a male patient diagnosed with PTC who underwent radical surgery and received I131 treatment. During the fourth year of follow-up, he developed cervical lymph node metastasis. Despite systemic treatment, the patient was hospitalized in the seventh year due to a recurrent cough and expectoration. Anti-infective therapies proved ineffective, and imaging revealed lung metastasis. An echocardiogram identified a hypoechoic mass measuring 5.3 cm by 3.2 cm in the right ventricle, attached to the lateral wall and between the anterior and posterior leaflets, indicating cardiac metastasis. Following diagnosis, the patient’s condition deteriorated rapidly, culminating in death due to heart failure and severe infection. It is well-established that thyroid cancer can metastasize through both hematogenous and lymphatic pathways, with the lungs and brain being the most common sites, followed by the bones and liver. Cardiac metastasis, however, is exceedingly rare, and clinical reports are scarce. This case underscores the importance of considering atypical metastatic sites in advanced thyroid cancer and highlights the aggressive potential of the disease in certain patients. We hope this case raises awareness among oncologists.