# Respiratory syncytial virus infection, non‐respiratory syncytial virus respiratory infections, and later wheezing

## TL;DR

This study finds that hospitalization for respiratory infections in early childhood is linked to wheezing later in life.

## Contribution

The study is the first in Japan to investigate the association between RSV and non-RSV infections and later wheezing in children.

## Key findings

- Hospitalization for RSV infection was associated with a 2.78 times higher odds of wheezing at age 3.
- Non-RSV respiratory infections were linked to a 2.61 times higher odds of wheezing.
- Respiratory-related disorders showed the strongest association with wheezing (OR = 3.33).

## Abstract

Studies investigating whether respiratory syncytial virus (RSV) infection, non‐RSV respiratory infections, respiratory‐related disorders, and non‐respiratory‐related disorders are associated with subsequent wheezing are limited in Japan. We aimed to elucidate the relationship between hospitalization for RSV infection, non‐RSV respiratory infections, respiratory‐related disorders, as well as non‐respiratory‐related disorders and subsequence wheezing in Japanese children.

This study included 7340 children and was conducted under the TMM BirThree Cohort Study (Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study). Data was collected from birth records and questionnaires. We categorized hospitalization history into five categories: “no hospitalization,” hospitalizations for “RSV infection,” “non‐RSV respiratory infections,” “respiratory‐related disorders,” and “non‐respiratory‐related disorders.” The association of the five categories with later wheezing at 3 years of age was evaluated using multivariable logistic regression analysis.

After adjusting for covariates, an association was shown between hospitalization under 2 years of age and later wheezing (odds ratio [OR] = 2.78; 95% confidence interval [CI] = 1.97–3.88 for “RSV infection”; OR = 2.61; 95% CI = 1.44–4.57 for “non‐RSV respiratory infections”; and OR = 3.33; 95% CI = 2.43–4.54 for “respiratory‐related disorders”).

Hospitalization of children under 2 years of age for RSV infection as well as non‐RSV respiratory infections and respiratory‐related disorders were associated with subsequent wheezing.