# Editorial: Mechanistic theories of aging

**Authors:** John Tower

PMC · DOI: 10.3389/fragi.2025.1617783 · 2025-05-12

## Full-text entities

- **Genes:** Hsp22 (Heat shock protein 22) [NCBI Gene 3772576] {aka 22, CG32041, CG4460, DmHsp22, Dmel20.8, Dmel\CG4460}, NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}, Smurf (SMAD specific E3 ubiquitin protein ligase) [NCBI Gene 36999] {aka CG4943, D-smurf, DSmurf, Dmel\CG4943, Dsmurf, LACK}
- **Diseases:** P. anserina (MESH:D002972), dehydration (MESH:D003681), neurodegenerative disease (MESH:D019636), Mitochondrial dysfunction (MESH:D028361), loss of muscle and bone mass (MESH:D001847), death (MESH:D003643), dementia (MESH:D003704), cardiovascular disease (MESH:D002318), Alzheimer's disease (MESH:D000544), Parkinson's disease (MESH:D010300), DR (MESH:D002313), starvation (MESH:D013217), infections (MESH:D007239), mitochondrial maintenance failure (MESH:D051437), inflammation (MESH:D007249)
- **Chemicals:** oleic acid (MESH:D019301), branched-chain amino acids (MESH:D000597), isoleucine (MESH:D007532), dafachronic acid (MESH:C533800), glucose (MESH:D005947), cholesterol (MESH:D002784), superoxide (MESH:D013481), carbon (MESH:D002244), methionine (MESH:D008715), Lipid (MESH:D008055), water (MESH:D014867), tryptophan (MESH:D014364), amino acid (MESH:D000596)
- **Species:** C. elegans [taxon 328850], Diptera (flies, order) [taxon 7147], Homo sapiens (human, species) [taxon 9606], Drosophila melanogaster (fruit fly, species) [taxon 7227], P. anserina [taxon 5145], Rodentia (rodent, order) [taxon 9989], Mus musculus (house mouse, species) [taxon 10090]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12104264/full.md

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Source: https://tomesphere.com/paper/PMC12104264