# A Case of Guillain-Barré Syndrome Possibly Associated With COVID-19 Infection

**Authors:** Rafail Giannas, Louiza Klironomou, Evgenia Skafida

PMC · DOI: 10.7759/cureus.82954 · 2025-04-24

## TL;DR

This paper reports a case of Guillain-Barré Syndrome possibly linked to a second infection with the virus that causes COVID-19.

## Contribution

The paper presents a confirmed case of GBS following reinfection with SARS-CoV-2, supporting emerging evidence of neurological complications.

## Key findings

- A case of Guillain-Barré Syndrome was confirmed after a patient experienced reinfection with SARS-CoV-2.
- This case adds to evidence suggesting a potential link between SARS-CoV-2 reinfection and neurological complications like GBS.

## Abstract

Guillain-Barré syndrome (GBS) is a neurological disorder characterized by progressive and symmetric muscle weakness accompanied by the absence or depression of deep tendon reflexes. It is typically associated with a preceding viral infection, such as the Epstein-Barr virus, cytomegalovirus, hepatitis E virus, and Zika virus, or bacterial pathogens like Campylobacter jejuni and Mycoplasma pneumoniae. Recently, rare cases of GBS have been reported following infection with COVID-19, suggesting a potential association between SARS-CoV-2 and GBS. In this report, we present a clinically and diagnostically confirmed case of GBS following COVID-19 reinfection, which supports emerging data on the neurological complications associated with subsequent episodes of infection by the novel coronavirus.

## Linked entities

- **Diseases:** Guillain-Barré syndrome (MONDO:0016218), COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** GBS (MESH:D020275), neurological disorder (MESH:D009461), muscle weakness (MESH:D018908), depression (MESH:D003866), infection (MESH:D007239), neurological complications (MESH:D002493), bacterial (MESH:D001424), Epstein-Barr virus (MESH:D020031), cytomegalovirus (MESH:D003586), COVID-19 (MESH:D000086382), viral infection (MESH:D014777)
- **Species:** Mycoplasmoides pneumoniae (Filterable agent of primary atypical pneumonia, species) [taxon 2104], hepatitis E virus [taxon 12461], Zika virus (no rank) [taxon 64320], Campylobacter jejuni (species) [taxon 197], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12103937/full.md

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Source: https://tomesphere.com/paper/PMC12103937