# Targeting the Odontogenic Keratocysts: Therapeutic Potential of 5-Fluorouracil Through Thymidylate Synthase Inhibition

## TL;DR

This paper explores the use of 5-fluorouracin to treat aggressive jaw cysts and reports on its effectiveness after surgery.

## Contribution

The paper presents a case study and literature review on using 5-FU for odontogenic keratocysts.

## Key findings

- 5-FU topical application showed potential in reducing recurrence of OKCs.
- A 12-month follow-up showed no recurrence after 5-FU treatment post-surgery.

## Abstract

Odontogenic keratocysts (OKCs) are aggressive cystic lesions of the jaw with a high recurrence rate. They are benign lesions that arise from dental lamina remnants or basal cells of the overlying epithelium. Various surgical and adjunctive treatments have been explored to minimize recurrence. In this report, we review the literature elucidating the efficacy of 5-fluorouracil (5-FU) topical application for recurrent OKCs and discuss the management of an OKC with 5-FU after enucleation and a 12-month follow-up.