# Effect of Oxybutynin on Detrusor Leak Point Pressure in Spinal Cord Injury Patients With Neurogenic Detrusor Overactivity: A Subgroup Analysis

## TL;DR

Oxybutynin reduces detrusor leak point pressure in spinal cord injury patients with neurogenic detrusor overactivity, particularly in specific subgroups.

## Contribution

The study identifies subgroups of spinal cord injury patients who benefit most from oxybutynin in reducing detrusor leak point pressure.

## Key findings

- Oxybutynin significantly reduced detrusor leak point pressure in patients with detrusor hyperreflexia and dyssynergia.
- Bladder compliance and capacity improved universally across all patients.
- Reductions in detrusor leak point pressure varied by injury level and duration.

## Abstract

Following spinal cord injury, neurogenic detrusor overactivity elevates detrusor leak point pressure, endangering renal function. This research examined oxybutynin's effects on detrusor leak point pressure and urodynamic parameters in 30 individuals with spinal cord injury and neurogenic detrusor overactivity, emphasizing variations across subgroups. Patients were given 5 mg of oxybutynin each day for a week, with urodynamic assessments conducted pre- and post-treatment. Decreases in detrusor leak point pressure were noted, especially among those with detrusor hyperreflexia combined with detrusor sphincter dyssynergia, cervical-level injuries, and injuries exceeding six months. Improvements in bladder compliance and capacity occurred universally, yet detrusor leak point pressure reductions differed by subgroup. Oxybutynin proves useful in reducing detrusor leak point pressure in vulnerable spinal cord injury patients, promoting its application in customized neurogenic detrusor overactivity care.