# Relationship Between Serum Hydrogen Sulfide and Ferritin Levels in Type 2 Diabetes Mellitus: A Retrospective Study at a Tertiary Hospital in Eastern India

## TL;DR

This study finds that people with type 2 diabetes have lower hydrogen sulfide and higher ferritin levels, suggesting oxidative stress is involved in the disease.

## Contribution

The paper reports a novel negative correlation between serum hydrogen sulfide and ferritin levels in type 2 diabetes patients.

## Key findings

- Type 2 diabetic patients had significantly lower serum H2S levels compared to controls.
- Serum ferritin levels were significantly higher in type 2 diabetes patients.
- A negative correlation was observed between H2S and ferritin levels in both cases and controls.

## Abstract

Introduction: Diabetes mellitus, one of the widespread endocrine disorders, is characterized by hyperglycemia. Hydrogen sulfide (H2S), a signaling gas transmitter, is involved in carbohydrate metabolism. The pathophysiology of β-cell dysfunction in type 1 and 2 diabetes may be significantly affected by alterations in the H2S balance. Diabetes mellitus causes an increase in ferritin, an acute-phase reactant.

Aims and objectives: This study aims to investigate the relationship between serum H2S and ferritin levels in patients with type 2 diabetes.

Methodology: Spectrophotometric measurements of serum H2S were made using a lab-standardized technique. Enzyme-linked immunosorbent assay (ELISA) was used with standardized kits (BioRad Laboratories, Hercules, CA, USA) to determine serum ferritin levels.

Results: Compared to the control group, type 2 diabetic patients had significantly greater serum ferritin levels and significantly lower H2S levels. H2S and ferritin levels are negatively correlated among cases and controls.

Conclusion: The negative connection between ferritin and H2S levels indicates that oxidative stress plays an important part in the beginning and development of diabetes mellitus.