# Oxcarbazepine Induced Rhabdomyolysis and Acute Kidney Injury: A Case Report

**Authors:** Sara Yavuz Ileri, Nuray Can Usta

PMC · DOI: 10.1155/crin/4168888 · Case Reports in Nephrology · 2025-05-16

## TL;DR

This case report highlights how oxcarbazepine, a drug used for epilepsy and nerve pain, can cause severe muscle damage and kidney injury.

## Contribution

The novelty is the rare documentation of oxcarbazepine-induced rhabdomyolysis leading to acute kidney injury.

## Key findings

- Oxcarbazepine was found to trigger rhabdomyolysis in a patient.
- The rhabdomyolysis subsequently caused acute kidney injury.
- The case underscores the importance of monitoring for serious side effects of commonly prescribed drugs.

## Abstract

The cause of acute skeletal muscle damage, defined as rhabdomyolysis, is multifactorial. Medicines are prominent among the most important reasons. The clinical significance of rhabdomyolysis lies in the fact that it can cause acute kidney injury (AKI) in 10%–40% of patients. In this presented case, oxcarbazepine, which is a preferred drug in the treatment of epilepsy and also in neuropathic pain in clinical practice, triggered rhabdomyolysis and subsequently caused the development of AKI. Through this case report, we aimed to emphasize that some serious side effects should not be forgotten when prescribing drugs in clinical practice.

## Linked entities

- **Chemicals:** oxcarbazepine (PubChem CID 34312)
- **Diseases:** rhabdomyolysis (MONDO:0005290), acute kidney injury (MONDO:0002492), epilepsy (MONDO:0005027)

## Full-text entities

- **Diseases:** epilepsy (MESH:D004827), AKI (MESH:D058186), neuropathic pain (MESH:D009437), muscle damage (MESH:D009133), Rhabdomyolysis (MESH:D012206)
- **Chemicals:** Oxcarbazepine (MESH:D000078330)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12101903/full.md

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Source: https://tomesphere.com/paper/PMC12101903