# Advanced heart disease classification based on multi-channel heart sound coupling features

**Authors:** Yu Fang, Dongbo Liu, Zijian Guo, Hongxia Leng, Xing Liu, Xiaochen Wu

PMC · DOI: 10.1371/journal.pone.0321209 · PLOS One · 2025-05-23

## TL;DR

This paper introduces a new method for classifying heart diseases by analyzing multi-channel heart sound signals, improving detection accuracy significantly.

## Contribution

The novel framework uses multi-channel coupling features to better capture pathological relationships in heart sounds.

## Key findings

- The method achieved 95.6% accuracy on congenital heart disease datasets.
- It reached 98.3% accuracy on the PhysioNet heart sound challenge dataset.
- Multi-channel coupling features outperform single-channel methods in capturing heart disease characteristics.

## Abstract

Conventional heart sound classification methods often rely on single-channel, one-dimensional feature extraction, which inadequately captures pathological relationships across different auscultation zones, thereby limiting the accuracy of heart disease detection. To address this issue, a novel classification framework based on multi-channel heart sound coupling feature extraction is proposed to enhance heart disease identification. This approach begins with denoising preprocessing applied to four-channel heart sound signals and a single-channel electrocardiogram. These five-channel signals are systematically paired to extract five types of coupling features, resulting in 130 distinct features per multi-channel sample. The ReliefF algorithm is then used to evaluate feature importance, retaining the top 20% of features to construct a coupling feature set. A convolutional neural network is employed to classify normal and abnormal heart sounds. When applied to clinical congenital heart disease datasets, the proposed method achieved a classification accuracy of 95.6%, while on the PhysioNet heart sound challenge dataset, it reached an accuracy of 98.3%. Experimental results demonstrate that compared to single-channel, one-dimensional features, multi-channel coupling features more effectively capture pathological characteristics in heart sound signals, significantly improving the accuracy of heart disease classification and addressing challenges in the refined categorization of cardiac conditions.

## Linked entities

- **Diseases:** congenital heart disease (MONDO:0005453)

## Full-text entities

- **Diseases:** heart disease (MESH:D006331), congenital heart disease (MESH:D006330)

## Full text

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## Figures

13 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12101697/full.md

## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12101697/full.md

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Source: https://tomesphere.com/paper/PMC12101697