# Clinical profile of alcohol dependent paintents according to Lesch Typology one year after the Covid-19 pandemic-comparative study

**Authors:** Dusan Kuljancic, Jelena Amidzic, Lazar Ljubotin, Djendji Siladji, Mina Cvjetkovic Bosnjak, Vladimir Knezevic, Dragana Ratkovic, Vanja Bosic, Vesna Vasic, Branislav Sakic, Sanja Bjelan, Minja Abazovic, Masa Comic, Predrag Savic, Souparno Mitra, Souparno Mitra, Souparno Mitra, Souparno Mitra

PMC · DOI: 10.1371/journal.pone.0324851 · PLOS One · 2025-05-23

## TL;DR

This study examines how the pandemic affected the clinical profiles of alcohol-dependent patients using Lesch Typology, finding no increase in anxious or depressive types.

## Contribution

The study provides a comparative analysis of alcohol dependence typology before and after the pandemic using Lesch Typology.

## Key findings

- No increase in type II (anxious) or type III (depressive) alcohol-dependent patients post-pandemic.
- Type III was the most common classification (50.9%) among alcohol-dependent patients.
- The study used a public domain software for data processing to classify patients.

## Abstract

The COVID-19 pandemics caused both physical and mental health problems raising global social tension, anxiety and discomfort which toghether lead to the increase in the consumption of psychoactive substances, among which alcohol was the most common, as a way of self-help. The hypothesis of this paper is the rising number of type II (anxious model) and type III (depressive model) alcohol dependent patients (as identified by the Lesch Typology) in the post-COVID-19 pandemic period compared to the pre-pandemic period, as a likely consequence of the stress, fear, problems and adversities that were caused by the pandemic.

The research was conducted as a retrospective cross-sectional study. It included 218 patients who were diagnosed with alcohol dependence. To classify the patients by the Lesch Typology, the MS Windows softer package for data processing available in public domain was used.

In relation to the Lesch Typology, 111 (50.9%) patients belonged to type III, 45 (20.6%) to type I, 37 (17.0%) to type II and 25 (11.5%) to type IV.

Compared to the pre-pandemic findings of alcohol dependents classification according to the Lesch Typology, there was no increase in types II and III after the COVID-19 pandemic.

## Linked entities

- **Diseases:** alcohol dependence (MONDO:0002046)

## Full-text entities

- **Diseases:** COVID-19 (MESH:D000086382), anxiety (MESH:D001007), type III (MESH:C536044), alcohol dependence (MESH:D000437), depressive (MESH:D003866), type II (MESH:D006938)
- **Chemicals:** alcohol (MESH:D000438), psychoactive substances (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

44 references — full list in the complete paper: https://tomesphere.com/paper/PMC12101639/full.md

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Source: https://tomesphere.com/paper/PMC12101639