# DLGAP5 mutations Disrupt Normal Chromosome Segregation and Spindle Formation of human Oocyte Meiosis and Lead to Female Infertility

**Authors:** Meng Wang, Zhou Li, Juepu Zhou, Rui Long, Qingsong Xi, Hong Gao, Youzhu Li, Lei Jin, Lixia Zhu

PMC · DOI: 10.1002/mco2.70224 · MedComm · 2025-05-22

## Full-text entities

- **Genes:** RMDN1 (regulator of microtubule dynamics 1) [NCBI Gene 51115] {aka CGI-90, FAM82B, RMD-1, RMD1}, MOS (MOS proto-oncogene, serine/threonine kinase) [NCBI Gene 4342] {aka MSV, OZEMA20}, DLGAP5 (DLG associated protein 5) [NCBI Gene 9787] {aka DLG7, HURP}
- **Diseases:** hepatocellular carcinoma (MESH:D006528), meiosis disorder (MESH:C536875), infertility (MESH:D007246), female infertility (MESH:D007247), cancer (MESH:D009369), ART failure (MESH:D051437)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Mutations:** c.1101C>G, p.Tyr367*

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## References

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Source: https://tomesphere.com/paper/PMC12099062