# Biological disturbance of MiR-425 and its application prospects in cardiovascular diseases

**Authors:** Shan Zhou, Bo Han

PMC · DOI: 10.3389/fcell.2025.1593241 · Frontiers in Cell and Developmental Biology · 2025-05-09

## TL;DR

MiR-425 is a molecule that may help treat heart diseases by reducing inflammation, aiding heart repair, and improving blood vessel growth.

## Contribution

The paper explores new roles of MiR-425 in regulating immune cells and cardiovascular functions for disease treatment.

## Key findings

- MiR-425 reduces inflammation and promotes heart repair in cardiovascular diseases.
- It improves the prediction of atherosclerosis and reduces cardiac fibrosis.
- MiR-425 regulates atrial natriuretic peptide to affect cardiovascular function.

## Abstract

MiR-425 is a biological molecule that has potential applications in cardiovascular diseases. It can regulate biological functions by combining with LncRNAs, binding with proteins, and changing the differentiation of immune cells. MiR-425 also has a role as a biomarker of disease. In cardiovascular diseases, it has clinical significance in reducing inflammation and heart repair, inducing angiogenesis, improving the prediction of atherosclerosis, reducing cardiac fibrosis, and regulating atrial natriuretic peptide to affect cardiovascular function. Target gene prediction and KEGG enrichment analysis are also mentioned.

## Linked entities

- **Genes:** MIR425 (microRNA 425) [NCBI Gene 494337]
- **Diseases:** atherosclerosis (MONDO:0005311)

## Full-text entities

- **Genes:** MIR425 (microRNA 425) [NCBI Gene 494337] {aka MIRN425, hsa-mir-425, mir-425}
- **Diseases:** cardiovascular diseases (MESH:D002318), cardiac fibrosis (MESH:D005355), inflammation (MESH:D007249), atherosclerosis (MESH:D050197)

## Full text

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## Figures

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## References

78 references — full list in the complete paper: https://tomesphere.com/paper/PMC12098596/full.md

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Source: https://tomesphere.com/paper/PMC12098596