# Nighttime sleep duration and the prevalence of hyperuricemia: a systematic review and network meta-analysis

## TL;DR

This study finds that both short and long nighttime sleep durations are linked to higher risk of hyperuricemia, with short sleep being more harmful.

## Contribution

The study provides a network meta-analysis comparing different sleep durations and their association with hyperuricemia risk.

## Key findings

- Short nighttime sleep duration increases hyperuricemia risk by 26% compared to normal sleep.
- Long nighttime sleep duration increases hyperuricemia risk by 19% compared to normal sleep.
- Short sleep duration is more harmful than long sleep duration for hyperuricemia risk.

## Abstract

According to clinical observation and recent studies, there is a significant association between night sleep duration and hyperuricemia. In this study, systematic review and network meta-analysis were performed to evaluate the risk of hyperuricemia associated with different nighttime sleep durations.

Seven databases were searched from database inception to March 2020. Two reviewers independently performed study selection, quality appraisal, and data extraction. Conventional meta-analysis was conducted using either a fixed-effects or random-effects model according to statistical heterogeneity. A Bayesian network meta-analysis was conducted using the consistency model.

Six studies with 416,684 patients and involving different nighttime sleep durations were included. The network meta-analysis showed that compared with normal nighttime sleep duration, the pooled risk ratio (RR) for short nighttime sleep duration was 1.26 (95% confidence interval [CI] 1.22–1.30, p < 0.00001). Compared with long nighttime sleep duration, pooled RR of HUA with normal nighttime sleep duration was 0.81 (95% CI 0.67–0.99, p = 0.03). Compared with long nighttime sleep duration, pooled RR of HUA with short nighttime sleep duration was 1.07 (95% CI 0.90–1.28, p = 0.43).

The evidence in this network meta-analysis illustrates that both short and long sleep duration increased the risk of hyperuricemia, and short sleep duration was more harmful. Further high-quality studies are required to explore the Mechanism of the nighttime sleep duration influencing hyperuricemia.

https://www.crd.york.ac.uk/, CRD42024519628.