# The influence of genetic factors on the severity of anxiety and depressive symptoms and the choice of coping strategies in reproductive tract cancer―a preliminary study

## TL;DR

This study explores how genetic variations in MAO-A and 5-HTT genes may influence anxiety, depression, and coping strategies in women with reproductive tract cancer.

## Contribution

The study is a preliminary investigation into the relationship between MAO-A and 5-HTT gene polymorphisms and coping strategies in reproductive tract cancer patients.

## Key findings

- No statistically significant differences in anxiety and depressive symptoms were found based on genotype.
- Patients with MAO-A 4/4 genotype showed a preference for constructive coping strategies like positive redefinition.
- 5-HTT gene polymorphism was associated with coping strategies such as anxious preoccupation and positive redefinition.

## Abstract

The aim of this study was to analyze the impact of polymorphisms within the promoters of the MAO-A and the 5-HTT (SLC6A4) genes on the severity of anxiety and depressive disorder symptoms, and adaptation to the disease in patients with reproductive tract cancer.

This study involved a group female patients treated at the Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents of the Pomeranian Medical University in Szczecin. The inclusion criteria for the study were advanced ovarian cancer or endometrial cancer, as well as treatment in the form of cytoreductive therapy and chemotherapy. The following standardized research tools were used to collect empirical data: Beck Depression Inventory, State–Trait Anxiety Inventory and Mini-Mental Adjustment to Cancer.

The study included 139 women diagnosed with endometrial cancer (63%) or ovarian cancer (37%). Assessment of the severity of anxiety and depressive symptoms in the studied group of patients depending on genotype did not show statistically significant differences. However, among patients with genotype MAO-A 4/4, the constructive style prevailed over the destructive one, and the most frequently chosen strategy was positive redefinition. In the case of patients with the 5-HTT gene polymorphism, the most frequently chosen strategies were anxious preoccupation and positive redefinition.

Searching for the relationship between genetic factors and the strategies adopted to cope with cancer requires intensive research. Undoubtedly, the severity of anxiety and depressive symptoms has an impact on adaptive behavior and the process of onco-logical treatment.