# Urosepsis From Nephrolithiasis Caused by Candida glabrata: A Rare Etiology of Urinary Sepsis in an Immunocompetent Patient

## TL;DR

A 41-year-old immunocompetent patient developed sepsis from a kidney stone caused by Candida glabrata, a rare fungal infection.

## Contribution

Reports a rare case of urosepsis caused by Candida glabrata in an immunocompetent patient with nephrolithiasis.

## Key findings

- Candida glabrata was identified as the cause of sepsis in a patient with a history of kidney stones.
- Treatment included intravenous micafungin and surgical stone removal.
- Fungal sepsis from nephrolithiasis is uncommon in immunocompetent individuals.

## Abstract

Nephrolithiasis can often serve as an infection nidus, as it is typically associated with urease-producing bacteria and can obstruct the urinary tract, leading to pyelonephritis. While most urinary tract infections from septic stones are bacterial in etiology, fungal causes are less commonly reported in immunocompetent patients and rarely manifest as fungemia. Among fungal causes, Candida albicans is the most common. We describe the case of a 41-year-old immunocompetent patient with a history of recurrent kidney stones and percutaneous nephrostomy tube placement, who developed sepsis from a urinary source secondary to a nephrolithiasis. Blood culture isolates grew Candida glabrata. Following identification of the fungus, the patient received a two-week intravenous micafungin course and outpatient stone removal per urological surgery.