Correction: MiR-137 promotes TLR4/NF-κB pathway activity through targeting KDM4 A, inhibits osteogenic diferentiation of human bone marrow mesenchymal stem cells and aggravates osteoporosis
Ying-feng Yu, Pei-quan Yao, Zhi-kun Wang, Wen-wei Xie
Abstract
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TopicsBone Metabolism and Diseases
Correction: J Orthop Surg Res, (2023)18:444
https://doi.org/10.1186/s13018-023–03918-y
In this article Figs. 2 and 6 appeared incorrectly and have now been corrected in the original publication. For completeness and transparency, the old incorrect versions are displayed below.
Incorrect Fig. 2Fig. 2. Osteogenic medium induces osteogenic differentiation of human bone marrow mesenchymal stem cells. A The expression levels of Runx2 and OCN in the CM and the OM groups detected by qRT-PCR. **P < 0.01. B Western blotting analysis of Runx2 and OCN protein levels in hBMSCs cultured in CM or OM for 7 days. **P < 0.01. C ALP staining to detect ALP activity of cells in the CM group and the OM group. *P < 0.05. D Alizarin Red staining to detect the mineralization ability of cells in the CM group and the OM group. *P < 0.05. hBMSCs human bone marrow mesenchymal stem cells; Runx2 runt-related transcription factor 2; OCN osteocalcin; CM standard culture medium; OM osteogenic medium
Corrected Fig. 2Fig. 2. Osteogenic medium induces osteogenic differentiation of human bone marrow mesenchymal stem cells. A The expression levels of Runx2 and OCN in the CM and the OM groups detected by qRT-PCR. **P < 0.01. B Western blotting analysis of Runx2 and OCN protein levels in hBMSCs cultured in CM or OM for 7 days. **P < 0.01. C ALP staining to detect ALP activity of cells in the CM group and the OM group. *P < 0.05. D Alizarin Red staining to detect the mineralization ability of cells in the CM group and the OM group. *P < 0.05. hBMSCs human bone marrow mesenchymal stem cells; Runx2 runt-related transcription factor 2; OCN osteocalcin; CM standard culture medium; OM osteogenic medium
Incorrect Fig. 6Fig. 6. MiR-137 regulates osteogenic differentiation of hBMSCs by targeting KDM4A. A The expression level of KDM4A in hBMSCs after KDM4A knockdown detected by qRT-PCR. B ALP staining results of the activity of ALP in each group of cells. C Alizarin Red staining results of the mineralization ability of each group of cells. D The protein levels of Runx2 and OCN in each group of cells detected by western blotting. **P < 0.01, vs. inhibitor NC + siNC; #P < 0.05, ##P < 0.01, vs. inhibitor-miR-137 + si-KDM4A. KDM4A lysine-specific demethylase 4A, hBMSCs human bone marrow mesenchymal stem cells, ALP alkaline phosphatase, Runx2 runt-related transcription factor 2, OCN osteocalcin
Correct Fig. 6Fig. 6. MiR-137 regulates osteogenic differentiation of hBMSCs by targeting KDM4A. A The expression level of KDM4A in hBMSCs after KDM4A knockdown detected by qRT-PCR. B ALP staining results of the activity of ALP in each group of cells. C Alizarin Red staining results of the mineralization ability of each group of cells. D The protein levels of Runx2 and OCN in each group of cells detected by western blotting. **P < 0.01, vs. inhibitor NC + siNC; #P < 0.05, ##P < 0.01, vs. inhibitor-miR-137 + si-KDM4A. KDM4A lysine-specific demethylase 4A, hBMSCs human bone marrow mesenchymal stem cells, ALP alkaline phosphatase, Runx2 runt-related transcription factor 2, OCN osteocalcin
The original article has been corrected.